Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway

• Published in: Medical science monitor Vol. 24; pp. 8592 - 8601
• Main Authors: Shao, Songjun, Zhang, Xiangning, Duan, Lingdi, Fang, Haiyan, Rao, Shanshan, Liu, Weijia, Guo, Bing, Zhang, Xiangyan
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 27.11.2018
• Subjects: Clinical Research

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and deposition of collagen in the ECM un...