New versatile approach to alpha-hydrazonoesters and amino acid derivatives through a modified Japp-Klingemann reaction

• Published in: Chemical communications (Cambridge, England) no. 15; pp. 1385 - 1386
• Main Authors: Atlan, El Kaim, L, Supiot, C
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2000
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; SALTS

Addition of diazonium tetrafluoroborates to an acyl chloride pyridine mixture affords hydrazonoacid derivatives in smooth conditions; this new Japp-Klingemann reaction emphasizes the synthetic potential of electrophilic addition to ketenes.