The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation

• Published in: Human reproduction update Vol. 31; no. 2; pp. 81 - 101
• Main Authors: Naderi, Nushin, Tavalaee, Marziyeh, Nasr-Esfahani, Mohammad Hossein
• Format: Journal Article
• Language: English
• Published: England 01.03.2025
• Subjects: Adenosine - analogs & derivatives; Adenosine - metabolism; DNA Methylation; Epigenesis, Genetic; Humans; Infertility, Male - etiology; Infertility, Male - genetics; Male; RNA - metabolism; RNA Methylation; Spermatogenesis - genetics; Spermatozoa - metabolism; Varicocele - genetics; Varicocele - metabolism; DNA methylation; spermatozoa; male infertility; m6A-RNA; epigenetics; varicocele

Varicocele is an abnormal dilation and torsion of the pampiniform venous plexus in the scrotum due to venous reflux, primarily affecting the left side. It affects 15% of men and is a prevalent contributor to male infertility. Varicocele is a complex disorder influenced by genetic, epigenetic, and en...