Regulation of rat glutamate-cysteine ligase (γ-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B1-induced preneoplasia

• Published in: Carcinogenesis (New York) Vol. 21; no. 10; pp. 1827 - 1834
• Main Authors: Shepherd, A.Graeme, Manson, Margaret M., Ball, Helen W.L., McLellan, Lesley I.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2000
• Subjects: activator protein 1; AFB1; aflatoxin B1; antioxidant-responsive element; AP-1; ARE; BHA; Biological and medical sciences; butylated hydroxyanisole; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; GGT; GLCL; GLCLC; GLCLR; glutamate-cysteine ligase; glutamate-cysteine ligase catalytic subunit; glutamate-cysteine ligase regulatory subunit; glutathione S-transferase; glutathione synthetase; GST; I3C; indole-3-carbinol; Medical sciences; NAD(P)H:quinone oxidoreductase; NQO; TNF-α; Tumors; tumour necrosis factor α; γ-glutamyltranspeptidase; Catalytic subunit; Rat; Liver; Hepatic disease; Supplemented diet; Anticarcinogen; Carcinogenesis; Kidney; Prevention; Enzymatic activity; Ligases; Glutathione transferase; Mechanism of action; Kidney disease; Glutamate-cysteine ligase; Urinary system disease; Premalignant lesion; Carbon-nitrogen ligases; Enzyme; Transferases; Rodentia; Oral administration; Regulatory subunit; Toxin; Carcinogen; Vertebrata; Mammalia; Treatment; Animal; Aflatoxin B1; Digestive diseases

Certain dietary constituents can protect against chemically induced carcinogenesis in rodents. A principal mechanism by which these chemopreventive compounds exert their protective effects is likely to be via induction of carcinogen detoxification. This can be mediated by conjugation with glutathion...