A novel mechanism of colon carcinoma cell adhesion to the endothelium triggered by beta 1 integrin chain

• Published in: The Journal of biological chemistry Vol. 269; no. 8; pp. 6124 - 6132
• Main Authors: Martìn-Padura, I, Bazzoni, G, Zanetti, A, Bernasconi, S, Elices, M J, Mantovani, A, Dejana, E
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 25.02.1994
• Subjects: Amino Acid Sequence; Antibodies, Monoclonal - immunology; Cell Adhesion; Cells, Cultured; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Endothelium, Vascular - cytology; Endothelium, Vascular - metabolism; Extracellular Matrix Proteins - metabolism; Humans; Integrin beta1; Integrins - immunology; Integrins - metabolism; Molecular Sequence Data; Receptors, Cell Surface - metabolism; Tumor Cells, Cultured

We have found a monoclonal antibody, called BV7, that rapidly stimulated by 6-10-folds HT-29 colon carcinoma cell adhesion to resting human umbilical vein endothelial cells. This effect was directed to tumor cells and not to endothelial cells and was cell-specific. BV7 was also active on the HCCP-29...