Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor

• Published in: The Journal of biological chemistry Vol. 270; no. 46; pp. 27720 - 27727
• Main Authors: Unson, Cecilia G., Cypess, Aaron M., Kim, Hyang Nina, Goldsmith, Paul K., Carruthers, Cynthia J.L., Merrifield, R.B., Sakmar, Thomas P.
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 01.11.1995

Glucagon receptor mutants were characterized with the aim of elucidating minimal structural requirements for proper biosynthesis, ligand binding, and adenylyl cyclase coupling. One N-terminal deletion mutant and five truncation mutants with progressively shorter C termini were expressed in transient...