Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule

• Published in: Microbial physiology Vol. 34; no. 1; pp. 108 - 120
• Main Authors: Schubert, Christopher, Unden, Gottfried
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2024
• Subjects: Aerobiosis; Carbon - metabolism; Catabolite Repression; Cyclic AMP - metabolism; Cyclic AMP Receptor Protein - genetics; Cyclic AMP Receptor Protein - metabolism; Dicarboxylic Acid Transporters - genetics; Dicarboxylic Acid Transporters - metabolism; DNA-Binding Proteins; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Gene Expression Regulation, Bacterial; Phosphoenolpyruvate Sugar Phosphotransferase System - genetics; Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism; Promoter Regions, Genetic; Protein Kinases; Research Article; Signal Transduction; Succinic Acid - metabolism; Transcription Factors; Aerobic C4-dicarboxylate metabolism; Carbon catabolite repression; C4-dicarboxylate transporter DctA; Succinate; Escherichia coli; Hierarchical carbon utilization
• ISSN: 2673-1665; 2673-1673; 2673-1673
• DOI: 10.1159/000538095

Abstract Introduction: C4-dicarboxylates (C4-DC) have emerged as significant growth substrates and signaling molecules for various Enterobacteriaceae during their colonization of mammalian hosts. Particularly noteworthy is the essential role of fumarate respiration during colonization of pathogenic...