Epithelial cells facilitate tissue fibrosis through early growth response-1 overexpression in IgG4-related disease

[Display omitted]

Saved in:
Bibliographic Details
Published inScience bulletin
Main Authors Sun, Ruijie, Luo, Qinhuan, Wang, Mu, Peng, Linyi, Wei, Wei, Li, Yanmei, Zhou, Jiaxin, Nie, Yuxue, Li, Jingna, Zhong, Qing, Fei, Yunyun, Li, Mengtao, Wu, Xunyao, Zhang, Wen
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2025
Online AccessGet full text

Cover

Abstract [Display omitted]
AbstractList [Display omitted]
Author Peng, Linyi
Li, Jingna
Li, Mengtao
Sun, Ruijie
Wang, Mu
Wei, Wei
Fei, Yunyun
Wu, Xunyao
Zhou, Jiaxin
Zhong, Qing
Li, Yanmei
Nie, Yuxue
Zhang, Wen
Luo, Qinhuan
Author_xml – sequence: 1
  givenname: Ruijie
  surname: Sun
  fullname: Sun, Ruijie
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 2
  givenname: Qinhuan
  surname: Luo
  fullname: Luo, Qinhuan
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 3
  givenname: Mu
  surname: Wang
  fullname: Wang, Mu
  organization: Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
– sequence: 4
  givenname: Linyi
  surname: Peng
  fullname: Peng, Linyi
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 5
  givenname: Wei
  surname: Wei
  fullname: Wei, Wei
  organization: Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin 300384, China
– sequence: 6
  givenname: Yanmei
  surname: Li
  fullname: Li, Yanmei
  organization: Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin 300384, China
– sequence: 7
  givenname: Jiaxin
  surname: Zhou
  fullname: Zhou, Jiaxin
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 8
  givenname: Yuxue
  surname: Nie
  fullname: Nie, Yuxue
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 9
  givenname: Jingna
  surname: Li
  fullname: Li, Jingna
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 10
  givenname: Qing
  surname: Zhong
  fullname: Zhong, Qing
  organization: Biomedical Engineering Facility of National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
– sequence: 11
  givenname: Yunyun
  surname: Fei
  fullname: Fei, Yunyun
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 12
  givenname: Mengtao
  surname: Li
  fullname: Li, Mengtao
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
– sequence: 13
  givenname: Xunyao
  surname: Wu
  fullname: Wu, Xunyao
  email: wuxunyao@pumch.cn
  organization: State Key Laboratory of Complex Severe and Rare Diseases, Clinical and Science Investigation Institute, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
– sequence: 14
  givenname: Wen
  surname: Zhang
  fullname: Zhang, Wen
  email: zhangwen91@sina.com
  organization: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40670200$$D View this record in MEDLINE/PubMed
BookMark eNp9kMFOwzAQRC0EolD6AxyQfyBhvXGdVOKCEJRKlbjA2XLsTesqTSI7LfD3pCr0yGlXqzejnblm503bEGO3AlIBQt1v0mh9mSLgNAWVghRn7AphNk1mWIjz055nIzaJcQMAQs5QQn7JRhJUDghwxcJz5_s11d7U3FJdR14Z62vfm55472PcEa98GdroI-_Xod2t1pxMqL_5KrSf_ZoHil3bREoEb_cU6KsbLtG3DfcNX6zmMglUD26OOx_JRLphF5WpI01-55h9vDy_P70my7f54ulxmVhE2SfC5ugyVaGrrFN5CaUo0JVFKVUh0BVAIocqk0iUG-NkpRSpTEzRYUFTwmzM7o6-3a7cktNd8FsTvvVf-AHAI2CHeDFQdUIE6EPJeqMPJetDyRqUHkoeRA9HEQ2v7z2FA0KNJecD2V671v8n_wF2HYaS
Cites_doi 10.1016/j.cels.2019.03.003
10.1038/s41587-023-01767-y
10.1038/nmeth.4402
10.3109/14397595.2014.1002968
10.1136/ard-2023-224363
10.1038/s41584-020-0500-7
10.3390/ijms21051664
10.1073/pnas.0506580102
10.1038/s41584-024-01135-3
10.1089/omi.2011.0118
10.1038/s41592-019-0667-5
ContentType Journal Article
Copyright 2025
Copyright_xml – notice: 2025
DBID AAYXX
CITATION
NPM
DOI 10.1016/j.scib.2025.06.041
DatabaseName CrossRef
PubMed
DatabaseTitle CrossRef
PubMed
DatabaseTitleList
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
EISSN 2095-9281
ExternalDocumentID 40670200
10_1016_j_scib_2025_06_041
S2095927325006760
Genre Journal Article
GroupedDBID --M
-SA
-S~
0R~
4.4
5VR
5XA
5XB
AAEDT
AAEDW
AAIAL
AAJKR
AAKOC
AALRI
AANXM
AAOAW
AAQFI
AARTL
AATTM
AAXKI
AAXUO
AAYIU
AAYQN
AAYTO
AAYWO
AAYZH
ABBBX
ABFSG
ABJNI
ABJOX
ABMAC
ABQEM
ABQYD
ABTHY
ABTMW
ABUDA
ACBXY
ACDAQ
ACGFS
ACIWK
ACKNC
ACPRK
ACRLP
ACSTC
ACVFH
ADBBV
ADCNI
ADKPE
ADRFC
ADVLN
AEBSH
AEGNC
AEHWI
AEIPS
AEJHL
AENEX
AEOHA
AEPYU
AEUPX
AEZWR
AFBBN
AFHIU
AFJKZ
AFLOW
AFPUW
AFRAH
AFTJW
AFUIB
AFXIZ
AFZHZ
AFZKB
AGCQF
AGJBK
AGQMX
AGUBO
AGWZB
AGYKE
AHAVH
AHBYD
AHJVU
AHSBF
AHWEU
AIEXJ
AIGII
AIIUN
AIIXL
AIKHN
AITUG
AIXLP
AJBLW
AJSZI
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMRAJ
ANKPU
APXCP
ASPBG
ATOGT
AUKKA
AVWKF
AXJTR
AZFZN
BGNMA
BJAXD
BKOJK
CAJEA
CCEZO
CCVFK
CHBEP
CJPJV
CSCUP
EBS
EFJIC
EFKBS
EJD
FDB
FIRID
FRRFC
FYGXN
H13
HX~
IXD
KOM
KOV
M41
M4Y
NU0
O9-
Q--
ROL
RSV
SOJ
SPC
SPCBC
SSE
SSK
SST
SSU
SSZ
T5K
TCJ
TGP
U1G
U5K
UG4
~G-
AAYXX
ABTEG
AGRNS
BNPGV
CITATION
NPM
ID FETCH-LOGICAL-c224t-1c72d36f2dfcd67b0b182db8b46812d80e170f342ee7aad4f66e63152d28e5e23
IEDL.DBID AIKHN
ISSN 2095-9273
IngestDate Fri Jul 18 01:40:20 EDT 2025
Thu Jul 31 00:26:09 EDT 2025
Sat Aug 16 17:01:10 EDT 2025
IsPeerReviewed true
IsScholarly true
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c224t-1c72d36f2dfcd67b0b182db8b46812d80e170f342ee7aad4f66e63152d28e5e23
PMID 40670200
ParticipantIDs pubmed_primary_40670200
crossref_primary_10_1016_j_scib_2025_06_041
elsevier_sciencedirect_doi_10_1016_j_scib_2025_06_041
PublicationCentury 2000
PublicationDate 2025-Jul-01
PublicationDateYYYYMMDD 2025-07-01
PublicationDate_xml – month: 07
  year: 2025
  text: 2025-Jul-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Science bulletin
PublicationTitleAlternate Sci Bull (Beijing)
PublicationYear 2025
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Hao, Stuart, Kowalski (b0030) 2024; 42
Fukui, Ogawa, Shimmura (b0010) 2015; 25
Havis, Duprez (b0015) 2020; 21
Perugino, Stone (b0055) 2020; 16
Qiu, Mao, Tang (b0035) 2017; 14
McGinnis, Murrow, Gartner (b0025) 2019; 8
Browaeys, Saelens, Saeys (b0045) 2020; 17
Baldini, Fulvio, La Rocca (b0005) 2024; 20
Subramanian, Tamayo, Mootha (b0050) 2005; 102
Yu, Wang, Han (b0040) 2012; 16
Li, Wang, Han (b0020) 2023; 82
Baldini (10.1016/j.scib.2025.06.041_b0005) 2024; 20
Subramanian (10.1016/j.scib.2025.06.041_b0050) 2005; 102
Li (10.1016/j.scib.2025.06.041_b0020) 2023; 82
Hao (10.1016/j.scib.2025.06.041_b0030) 2024; 42
Browaeys (10.1016/j.scib.2025.06.041_b0045) 2020; 17
Perugino (10.1016/j.scib.2025.06.041_b0055) 2020; 16
Yu (10.1016/j.scib.2025.06.041_b0040) 2012; 16
Fukui (10.1016/j.scib.2025.06.041_b0010) 2015; 25
McGinnis (10.1016/j.scib.2025.06.041_b0025) 2019; 8
Qiu (10.1016/j.scib.2025.06.041_b0035) 2017; 14
Havis (10.1016/j.scib.2025.06.041_b0015) 2020; 21
References_xml – volume: 16
  start-page: 284
  year: 2012
  end-page: 287
  ident: b0040
  article-title: ClusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS
– volume: 21
  start-page: 1664
  year: 2020
  ident: b0015
  article-title: EGR1 transcription factor is a multifaceted regulator of matrix production in tendons and other connective tissues
  publication-title: Int J Mol Sci
– volume: 8
  start-page: 329
  year: 2019
  end-page: 337
  ident: b0025
  article-title: DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors
  publication-title: Cell Syst
– volume: 25
  start-page: 737
  year: 2015
  end-page: 743
  ident: b0010
  article-title: Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz’s disease
  publication-title: Mod Rheumatol
– volume: 14
  start-page: 979
  year: 2017
  end-page: 982
  ident: b0035
  article-title: Reversed graph embedding resolves complex single-cell trajectories
  publication-title: Nat Methods
– volume: 16
  start-page: 702
  year: 2020
  end-page: 714
  ident: b0055
  article-title: IgG4-related disease: an update on pathophysiology and implications for clinical care
  publication-title: Nat Rev Rheumatol
– volume: 82
  start-page: 1348
  year: 2023
  end-page: 1358
  ident: b0020
  article-title: Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
  publication-title: Ann Rheum Dis
– volume: 42
  start-page: 293
  year: 2024
  end-page: 304
  ident: b0030
  article-title: Dictionary learning for integrative, multimodal and scalable single-cell analysis
  publication-title: Nat Biotechnol
– volume: 17
  start-page: 159
  year: 2020
  end-page: 162
  ident: b0045
  article-title: NicheNet: modeling intercellular communication by linking ligands to target genes
  publication-title: Nat Methods
– volume: 20
  start-page: 473
  year: 2024
  end-page: 491
  ident: b0005
  article-title: Update on the pathophysiology and treatment of primary Sjögren syndrome
  publication-title: Nat Rev Rheumatol
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: b0050
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc Natl Acad Sci USA
– volume: 8
  start-page: 329
  year: 2019
  ident: 10.1016/j.scib.2025.06.041_b0025
  article-title: DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors
  publication-title: Cell Syst
  doi: 10.1016/j.cels.2019.03.003
– volume: 42
  start-page: 293
  year: 2024
  ident: 10.1016/j.scib.2025.06.041_b0030
  article-title: Dictionary learning for integrative, multimodal and scalable single-cell analysis
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-023-01767-y
– volume: 14
  start-page: 979
  year: 2017
  ident: 10.1016/j.scib.2025.06.041_b0035
  article-title: Reversed graph embedding resolves complex single-cell trajectories
  publication-title: Nat Methods
  doi: 10.1038/nmeth.4402
– volume: 25
  start-page: 737
  year: 2015
  ident: 10.1016/j.scib.2025.06.041_b0010
  article-title: Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz’s disease
  publication-title: Mod Rheumatol
  doi: 10.3109/14397595.2014.1002968
– volume: 82
  start-page: 1348
  year: 2023
  ident: 10.1016/j.scib.2025.06.041_b0020
  article-title: Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard-2023-224363
– volume: 16
  start-page: 702
  year: 2020
  ident: 10.1016/j.scib.2025.06.041_b0055
  article-title: IgG4-related disease: an update on pathophysiology and implications for clinical care
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/s41584-020-0500-7
– volume: 21
  start-page: 1664
  year: 2020
  ident: 10.1016/j.scib.2025.06.041_b0015
  article-title: EGR1 transcription factor is a multifaceted regulator of matrix production in tendons and other connective tissues
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21051664
– volume: 102
  start-page: 15545
  year: 2005
  ident: 10.1016/j.scib.2025.06.041_b0050
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506580102
– volume: 20
  start-page: 473
  year: 2024
  ident: 10.1016/j.scib.2025.06.041_b0005
  article-title: Update on the pathophysiology and treatment of primary Sjögren syndrome
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/s41584-024-01135-3
– volume: 16
  start-page: 284
  year: 2012
  ident: 10.1016/j.scib.2025.06.041_b0040
  article-title: ClusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS
  doi: 10.1089/omi.2011.0118
– volume: 17
  start-page: 159
  year: 2020
  ident: 10.1016/j.scib.2025.06.041_b0045
  article-title: NicheNet: modeling intercellular communication by linking ligands to target genes
  publication-title: Nat Methods
  doi: 10.1038/s41592-019-0667-5
SSID ssj0001492407
ssib060475419
ssib054405809
Score 2.4299016
SecondaryResourceType online_first
Snippet [Display omitted]
SourceID pubmed
crossref
elsevier
SourceType Index Database
Publisher
Title Epithelial cells facilitate tissue fibrosis through early growth response-1 overexpression in IgG4-related disease
URI https://dx.doi.org/10.1016/j.scib.2025.06.041
https://www.ncbi.nlm.nih.gov/pubmed/40670200
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwELVKe-GCKGtZKh84gFDUxHaWHquqpWWpKqAStyiO7VKE0qoNEp_PTOKyXEDimEh2ovFknp_zZoaQMxGlkWtC4_h4fC9CzpwkUW1HtQ0CaiJkWghkR8FgIq6f_KcK6a5zYVBWaWN_GdOLaG3vtKw1W4vZrPXA8AgL0BdAHEJuALy9xgBd3SqpdYY3g9HXUYtoI2_BNnMudiaEMTZ9plR6wewSmCLzi0qewvsDor7hT3-bbNmNI-2U71YnFZ3tkLr9NFf03NaPvtgly94CEy1ewbMonsuvqEnSshi3pnlhaGqAJc9XsxW1fXqoxkLHdAqkPH-my1I4qx2PosJTv1u1bEZnGR1Or4RTpMBoRe3_nT0y6fceuwPHtlZwUsDs3PHSkCkeGKZMqoJQuhJ4hpKRFFiPTEWu9kLXcMG0DmHthAkCHXDAesUi7WvG90k1m2f6kFDg1zwVUSIlsh8pEy9QKYfAoTmHvaBukMu1NeNFWUEjXkvLXmK0fYy2j1FfJ7wG8dcGj3_4QQwh_tdxB-XqfD5DYAYSxICjf854TDbxqpTmnpBqvnzTp7AByWUTHKx7fztuWkdrko3R-O4De3LbrA
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDI4mdoALYjzHMwcOIFStbdLHjtO00bGxC5u0W9U0yRhC3bQViZ-P3aY8LiBxbZW0clzbn_vZJuSah2lo60BbHqbvecBcK0lk25JtjQ414SItCLJjP5ryh5k3q5FuVQuDtEpj-0ubXlhrc6VlpNlaLRatJxdTWOB9wYmDyfUBt9exOxWoeb0zGEbjr1QLbyNuwTFzNk4mhDWmfKZkesHuApCi6xWdPLnzh4v65n_6e2TXBI60U75bg9RUtk8a5tPc0BvTP_r2gKx7Kyy0eAXNopiX31CdpGUzbkXzQtBUA0pebhYbaub0UIWNjukcQHn-TNclcVZZDkWGp3o3bNmMLjI6mN9zqyiBUZKa_zuHZNrvTbqRZUYrWCn47Nxy0sCVzNeu1Kn0A2ELwBlShIJjPzIZ2soJbM24q1QAZ8e17yufga-Xbqg85bIjspUtM3VCKOBrlvIwEQLRjxCJ48uUgeFQjEEsqJrkrpJmvCo7aMQVtewlRtnHKPsY-XXcaRKvEnj8Qw9iMPG_rjsuT-fzGRwrkMAGnP5zxyuyHU0eR_FoMB6ekR28U9J0z8lWvn5TFxCM5OLSKNsH49Tb-g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epithelial+cells+facilitate+tissue+fibrosis+through+early+growth+response-1+overexpression+in+IgG4-related+disease&rft.jtitle=Science+bulletin+%28Beijing%29&rft.au=Sun%2C+Ruijie&rft.au=Luo%2C+Qinhuan&rft.au=Wang%2C+Mu&rft.au=Peng%2C+Linyi&rft.date=2025-07-01&rft.pub=Elsevier+B.V&rft.issn=2095-9273&rft_id=info:doi/10.1016%2Fj.scib.2025.06.041&rft.externalDocID=S2095927325006760
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2095-9273&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2095-9273&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2095-9273&client=summon