Mutations of the [beta] myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis

• Published in: Heart (British Cardiac Society) Vol. 89; no. 10; p. 1179
• Main Authors: Woo, A, Rakowski, H, Liew, J C, Zhao, M-S, Liew, C-C, Parker, T G, Zeller, M, Wigle, E D, Sole, M J
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.10.2003
• Subjects: Cardiomyopathy; Defects; Deoxyribonucleic acid; DNA; Genes; Genetic testing; Genotype & phenotype; Hospitals; Mutation; Proteins; Studies

Objectives: To assess patients with different types of mutations of the β myosin heavy chain (β MHC) gene causing hypertrophic cardiomyopathy (HCM) and to determine the prognosis of patients according to the affected functional domain of β MHC. Design and setting: Cohort study of subjects referred t...