TRPV1 Is Associated with Testicular Apoptosis in Mice
Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in...
Saved in:
| Published in | Journal of animal reproduction & biotechnology (Online) Vol. 34; no. 4; pp. 311 - 317 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
The Korean Society of Animal Reproduction and Biotechnology
01.12.2019
사단법인 한국동물생명공학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2671-4639 2671-4663 |
| DOI | 10.12750/JARB.34.4.311 |
Cover
| Abstract | Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging. |
|---|---|
| AbstractList | Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging. KCI Citation Count: 1 Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging. |
| Author | Shin, Eui-Jung Kim, Eun-Jin Kim, Chang-Woon Han, Jaehee Nyiramana, Marie Merci Hong, Seong-Geun Kang, Dawon Siregar, Adrian S. Lee, Dong Kun |
| Author_xml | – sequence: 1 givenname: Adrian S. surname: Siregar fullname: Siregar, Adrian S. organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea – sequence: 2 givenname: Marie Merci surname: Nyiramana fullname: Nyiramana, Marie Merci organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea – sequence: 3 givenname: Eun-Jin surname: Kim fullname: Kim, Eun-Jin organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea – sequence: 4 givenname: Eui-Jung surname: Shin fullname: Shin, Eui-Jung organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea – sequence: 5 givenname: Chang-Woon surname: Kim fullname: Kim, Chang-Woon organization: Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Korea – sequence: 6 givenname: Dong Kun surname: Lee fullname: Lee, Dong Kun organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea – sequence: 7 givenname: Seong-Geun surname: Hong fullname: Hong, Seong-Geun organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea – sequence: 8 givenname: Jaehee surname: Han fullname: Han, Jaehee organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea – sequence: 9 givenname: Dawon surname: Kang fullname: Kang, Dawon organization: Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea |
| BackLink | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002545365$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNp1UMtOwzAQtFCRKKVXzrlySPBjbafHUPEoKgJVhavlOE4xDXFlByH-npACByROs7uaGc3OMRq1vrUInRKcESo5Pr8tVhcZgwwyRsgBGlMhSQpCsNHvzGZHaBqjKzHnMs8hJ2PE16uHJ5IsYlLE6I3Tna2Sd9c9J2sbO2feGh2SYud3nY8uJq5N7pyxJ-iw1k2002-coMery_X8Jl3eXy_mxTI1lAJJ6xKAYKCUATdc95vQdVnVhuCcaGswEXXONTCGJSflDGsOlldmBqWRkjI2QWd73zbUamuc8toNuPFqG1SxWi-UAJLLnPbcxZ5bef2idsG96vAxCIaDDxulQ_9RY1WfQ4C0FlPDgRhZCgslUCt4jW0peO8Fey8TfIzB1sq4TnfOt13QrlEEq6F19dW6YqBA9a33suyP7CfGP4JPAamCfA |
| CitedBy_id | crossref_primary_10_3390_ani15050656 crossref_primary_10_3390_md19110614 crossref_primary_10_1007_s11010_022_04469_2 crossref_primary_10_3390_ijms251810199 crossref_primary_10_12750_JARB_38_4_291 crossref_primary_10_12750_JARB_36_3_145 crossref_primary_10_12750_JARB_35_4_315 crossref_primary_10_12750_JARB_37_2_87 crossref_primary_10_12750_JARB_39_2_81 crossref_primary_10_3390_ijms24087542 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION DOA ACYCR |
| DOI | 10.12750/JARB.34.4.311 |
| DatabaseName | CrossRef DOAJ Directory of Open Access Journals Korean Citation Index |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture |
| EISSN | 2671-4663 |
| EndPage | 317 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_6418782 oai_doaj_org_article_446647ee02c541c7b6e4b42e65f0eb65 10_12750_JARB_34_4_311 |
| GroupedDBID | AAYXX ALMA_UNASSIGNED_HOLDINGS CITATION GROUPED_DOAJ M1Z M~E OK1 ACYCR |
| ID | FETCH-LOGICAL-c2241-fb4410422345c5ab446afbdfc1081aec016f85a4330751b90a54e5dc94bc77233 |
| IEDL.DBID | DOA |
| ISSN | 2671-4639 |
| IngestDate | Sun Mar 09 07:55:12 EDT 2025 Wed Aug 27 01:32:04 EDT 2025 Tue Jul 01 02:41:08 EDT 2025 Thu Apr 24 22:54:44 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c2241-fb4410422345c5ab446afbdfc1081aec016f85a4330751b90a54e5dc94bc77233 |
| Notes | http://www.e-jarb.org/journal/view.html?uid=2500&vmd=Full |
| OpenAccessLink | https://doaj.org/article/446647ee02c541c7b6e4b42e65f0eb65 |
| PageCount | 7 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_6418782 doaj_primary_oai_doaj_org_article_446647ee02c541c7b6e4b42e65f0eb65 crossref_citationtrail_10_12750_JARB_34_4_311 crossref_primary_10_12750_JARB_34_4_311 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-12 |
| PublicationDateYYYYMMDD | 2019-12-01 |
| PublicationDate_xml | – month: 12 year: 2019 text: 2019-12 |
| PublicationDecade | 2010 |
| PublicationTitle | Journal of animal reproduction & biotechnology (Online) |
| PublicationYear | 2019 |
| Publisher | The Korean Society of Animal Reproduction and Biotechnology 사단법인 한국동물생명공학회 |
| Publisher_xml | – name: The Korean Society of Animal Reproduction and Biotechnology – name: 사단법인 한국동물생명공학회 |
| SSID | ssib055788481 ssj0002785674 ssib053376818 |
| Score | 2.0885265 |
| Snippet | Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes.... |
| SourceID | nrf doaj crossref |
| SourceType | Open Website Enrichment Source Index Database |
| StartPage | 311 |
| SubjectTerms | aging apoptosis mice testes trpv1 receptor 축산학 |
| Title | TRPV1 Is Associated with Testicular Apoptosis in Mice |
| URI | https://doaj.org/article/446647ee02c541c7b6e4b42e65f0eb65 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002545365 |
| Volume | 34 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 한국동물생명공학회지, 2019, 34(4), , pp.311-317 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pa8IwFA7D03YY-8ncL8IY7FRt7Etqj3UoTnAM0eEtNGkizlFF3XV_-17a6txh7LJDW1pSUr6-5vte8_hCyL1A5NOUp54BG3qgReAh74CHWzO0zq0kL6LpP4vuCHpjPt5Z6svVhBX2wAVwdTffCKExfkNzYDpUwoCChhHc-kaJ3L3Uj_ydZAojCTUMyujvUZdjXG5949-K6TYucovmhggxiUKeLh0dnd95vRcPWrUAaoApLfvBWLmxP_JQtrQ7PNQ5IoelgKRx8eDHZM9kJ-QgnixLEw1zSvhw8PLK6NOKbsA3KXU_XOnQeWrklac0XswX6_lquqLTjPZxuDgjo057-Nj1yuURPO1417MKpYyz8AqAa57gmUisSq1mSPOJ0SjmbJMnEOBnzJmK_ISD4amOQGnU1EFwTirZPDMXhIJQgqWR72tmQWiWMBuJRtrkJuFMKL9KvA0EUpfe4W4Ji3fpcggHmXSQyQAkSISsSh627ReFa8avLVsO0W0r53adX8AYkGUMyL9ioEru8H3ImZ7m97vjZC5nS4k5wZMUwJqogy7_o6crso-KKSrqWa5JZb38MDeoStbqNg9A3Pc_21-RQ9V8 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=TRPV1+Is+Associated+with+Testicular+Apoptosis+in+Mice&rft.jtitle=Journal+of+animal+reproduction+%26+biotechnology+%28Online%29&rft.au=Adrian+S.+Siregar&rft.au=Marie+Merci+Nyiramana&rft.au=%EA%B9%80%EC%9D%80%EC%A7%84&rft.au=%EC%8B%A0%EC%9D%98%EC%A0%95&rft.date=2019-12-01&rft.pub=%EC%82%AC%EB%8B%A8%EB%B2%95%EC%9D%B8+%ED%95%9C%EA%B5%AD%EB%8F%99%EB%AC%BC%EC%83%9D%EB%AA%85%EA%B3%B5%ED%95%99%ED%9A%8C&rft.issn=2671-4639&rft.eissn=2671-4663&rft.spage=311&rft.epage=317&rft_id=info:doi/10.12750%2FJARB.34.4.311&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_6418782 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2671-4639&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2671-4639&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2671-4639&client=summon |