Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability

• Published in: The FASEB journal Vol. 38; no. 15; p. e23870
• Main Authors: Guo, Di, Xiong, Hongbo, Yang, Zhongcheng, Zhang, Rui, Shi, Pengcheng, Yao, Yufeng, Liu, Mugen, Xu, Chengqi, Wang, Qing K
• Format: Journal Article
• Language: English
• Published: United States 15.08.2024
• Subjects: Animals; Cell Differentiation; Cell Proliferation; Hematopoiesis - physiology; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Lysosomal-Associated Membrane Protein 2 - genetics; Lysosomal-Associated Membrane Protein 2 - metabolism; Lysosomes - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Zebrafish; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; TMEM106B; hematopoiesis; zebrafish; hematopoietic stem and progenitor cells (HSPCs); hematopoietic stem cells (HSCs); LAMP2A

Hematopoietic stem and progenitor cells (HSPCs) are successfully employed for hematological transplantations, and impaired HSPC function causes hematological diseases and aging. HSPCs maintain the lifelong homeostasis of blood and immune cells through continuous self-renewal and maintenance of the m...