Anti-Apoptosis and Cell Survival Gene Expression Profile in LAD2 Cells

• Published in: Journal of allergy and clinical immunology Vol. 137; no. 2; p. AB76
• Main Authors: Kirshenbaum, Arnold S., MD, FAAAAI, Leerkes, Maarten, PhD, Desai, Avanti, MS, Metcalfe, Dean D., MD
• Format: Journal Article
• Language: English
• Published: St. Louis Elsevier Inc 01.02.2016; Elsevier Limited
• Subjects: Allergy and Immunology; Apoptosis; Cell cycle; Gene expression; Kinases; Mutation

The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization.