Anti-Apoptosis and Cell Survival Gene Expression Profile in LAD2 Cells
The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization.
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| Published in | Journal of allergy and clinical immunology Vol. 137; no. 2; p. AB76 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
St. Louis
Elsevier Inc
01.02.2016
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization. |
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| AbstractList | The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization. |
| Author | Kirshenbaum, Arnold S., MD, FAAAAI Leerkes, Maarten, PhD Desai, Avanti, MS Metcalfe, Dean D., MD |
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| Copyright | 2016 Copyright Elsevier Limited Feb 2016 |
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| DOI | 10.1016/j.jaci.2015.12.256 |
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| SubjectTerms | Allergy and Immunology Apoptosis Cell cycle Gene expression Kinases Mutation |
| Title | Anti-Apoptosis and Cell Survival Gene Expression Profile in LAD2 Cells |
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