Anti-Apoptosis and Cell Survival Gene Expression Profile in LAD2 Cells

The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 137; no. 2; p. AB76
Main Authors Kirshenbaum, Arnold S., MD, FAAAAI, Leerkes, Maarten, PhD, Desai, Avanti, MS, Metcalfe, Dean D., MD
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2016
Elsevier Limited
Subjects
Allergy and Immunology
Apoptosis
Cell cycle
Gene expression
Kinases
Mutation
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Summary:The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.256