Inhibition of Vascular Endothelial Abl1 Signaling Protects Against Food-Induced Anaphylaxis in Mice

Methods We employed BALB/c wild-type (WT), intestinal IL-9Tg and VE-specific Abl1 kinase-deficient (Cdh5CreAbl1fl/fl) mice and pharmacologic inhibitors (Imatinib) and models of anaphylaxis to determine the requirement of Abl1 kinase in IgE-mediated reactions.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 139; no. 2; p. AB277
Main Authors Hogan, Simon P., PhD, Waggoner, Lisa, MS, Wu, David, PhD, Yamani, Amnah N., MS
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2017
Elsevier Limited
Subjects
Allergy and Immunology
Rodents
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Summary:Methods We employed BALB/c wild-type (WT), intestinal IL-9Tg and VE-specific Abl1 kinase-deficient (Cdh5CreAbl1fl/fl) mice and pharmacologic inhibitors (Imatinib) and models of anaphylaxis to determine the requirement of Abl1 kinase in IgE-mediated reactions.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.890