Rh-Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers
Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst l...
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| Published in | European journal of organic chemistry Vol. 26; no. 34 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
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06.09.2023
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| Abstract | Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position. |
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| AbstractList | Abstract
Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom‐economic rhodium and thiophenol co‐catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all‐carbon quaternary center at the C3‐position. Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom‐economic rhodium and thiophenol co‐catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all‐carbon quaternary center at the C3‐position.Xiao-Hui Yang was nominated to be part of this collection by EurJOC Board Member Feng Shi Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position. |
| Author | Wang, Yi-Xin Wang, Zhen Yang, Xiao-Hui |
| Author_xml | – sequence: 1 givenname: Zhen surname: Wang fullname: Wang, Zhen organization: Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Minist Ind & Informat Technol, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharmac, Beijing 100081, Peoples R China – sequence: 2 givenname: Yi-Xin orcidid: 0000-0002-6617-4842 surname: Wang fullname: Wang, Yi-Xin organization: Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Minist Ind & Informat Technol, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharmac, Beijing 100081, Peoples R China – sequence: 3 givenname: Xiao-Hui orcidid: 0000-0001-6884-2587 surname: Yang fullname: Yang, Xiao-Hui email: xhyang@bit.edu.cn organization: Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Minist Ind & Informat Technol, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharmac, Beijing 100081, Peoples R China |
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| Keywords | ACID 1,3-DIENES UNACTIVATED ALKENES FUNCTIONALIZATION heteroarenes indoles CONSTRUCTION hydroheteroarylation styrenes INDOLE ALKALOIDS FRIEDEL-CRAFTS ALKYLATION HYDROCARBOFUNCTIONALIZATION DERIVATIVES HYDROARYLATION rhodium |
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| Snippet | Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol... Abstract Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom‐economic rhodium and... Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom‐economic rhodium and thiophenol... |
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| SubjectTerms | Alkylation Carbon Chemistry Chemistry, Organic Indoles Physical Sciences Rhodium Science & Technology Styrenes |
| Title | Rh-Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All-Carbon Quaternary Centers |
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