Development, preparation and safety testing of a Clostridium welchii Type C toxoid. II. Laboratory evaluation of potency

• Published in: Journal of biological standardization Vol. 7; no. 4; pp. 373 - 381
• Main Authors: Knight, P.A., Lucken, R.N., Foster, W., Walker, P.D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Science (USA) 1979
• Subjects: Animals; Biological Assay; Clostridium Infections - prevention & control; Clostridium perfringens - immunology; Dose-Response Relationship, Immunologic; Guinea Pigs; Mice; Reference Standards; Regression Analysis; Toxoids - administration & dosage; Toxoids - standards; Vaccination

The results obtained with four laboratory tests on four candidate formulations of Clostridium welchii Type C vaccine for use in man have been compared with clinical responses to the same vaccines. Quantal response assays in mice appeared to reflect the ranking of the four vaccines in human subjects...