Inactivation of Cronobacter sakazaki by phloretin: Molecular insights into targeting SdiA and practical applications

• Published in: Food science & technology Vol. 206; p. 116533
• Main Authors: Cao, Yifang, Zhang, Yan, Xie, Yijia, Xiao, Xinglong, Ren, Jiahao, Lou, Wenyong, Liu, Fengsong
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15.08.2024
• Subjects: C. sakazakii; Environmental resistance; Molecular dynamics; Phloretin; SdiA; Molecular dynamics; C. sakazakii; Environmental resistance; Phloretin; SdiA

The quorum sensing receptor SdiA is vital for the environmental resistance of Cronobacter sakazakii, facilitating its survival in powdered infant formula (PIF). In this study, a three-dimensional model of the SdiA receptor was developed, and molecular docking was used to screen inhibitors targeting...