Biological evaluation of integrin α3β1-targeted 68Ga-labeled HEVNPs in HCT 116 colorectal tumor-bearing mice

• Published in: European journal of pharmaceutical sciences Vol. 180; p. 106336
• Main Authors: Lambidis, Elisavet, Chen, Chun-Chieh, Lumen, Dave, Sánchez, Ana Isabel Fraguas, Sarparanta, Mirkka, Cheng, R. Holland, Airaksinen, Anu J.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2023
• Subjects: DOTA; Gallium-68; HCT 116 colorectal cancer cells; Hepatitis E viral nanoparticles; LXY30; Virus-like particle; DOTA; Virus-like particle; LXY30; Gallium-68; Hepatitis E viral nanoparticles; HCT 116 colorectal cancer cells

•Simple functionalization of the targeted-HEVNPs, HEVNP-LXY30, with DOTA.•[68Ga]Ga-DOTA-HEVNP-LXY30 production in high efficiency and excellent purity.•Comparison of targeting capability toward murine breast & human colon cancer cells.•Highly sufficient targeting toward integrin α3β1-expressing...