Considerations in Launching an International Multisite Clinical Trial

• Published in: Nursing research (New York) Vol. 74; no. 5; p. 391
• Main Authors: Kalvas, Laura Beth, Perry-Eaddy, Mallory A, Cassidy, Amy, Dawkins-Henry, Onella S, Lee, Laurie, Asaro, Lisa A, Wypij, David, Curley, Martha A Q
• Format: Journal Article
• Language: English
• Published: United States 04.04.2025
• Subjects: Humans; Internationality; Multicenter Studies as Topic - methods; Patient Selection; Randomized Controlled Trials as Topic - methods; United States; United States; study start-up; international research; randomized controlled trials; multicenter trials

Adequately powered randomized controlled clinical trials (RCTs) provide the highest level of evidence to support nursing interventions that are thought to improve clinical outcomes. To ensure adequate power, recruitment at multiple study sites is often required. Complexity is exponentiated when RCTs...