Laminin Receptors in the CNS and Vasculature

• Published in: Stroke (1970) Vol. 56; no. 8; pp. 2348 - 2359
• Main Author: Yao, Yao
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.08.2025
• Subjects: Animals; Blood Vessels - metabolism; Central Nervous System - embryology; Central Nervous System - metabolism; Dystroglycans - metabolism; Humans; Integrins - metabolism; Laminin - metabolism; Mice; Mice, Knockout; Receptors, Laminin - genetics; Receptors, Laminin - metabolism; knockout; animal models; laminin; dystroglycan; integrin

Laminin exerts a variety of important functions via binding to its receptors, including integrins and dystroglycan. With the advance in gene-targeting technology, many integrin/dystroglycan knockout/mutant mice were generated in the past 3 decades. These mutants enable loss-of-function studies and h...