Hypoxia-inducible factor (HIF)-3α is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2

• Published in: The international journal of biochemistry & cell biology Vol. 42; no. 7; pp. 1189 - 1200
• Main Authors: Pasanen, Annika, Heikkilä, Minna, Rautavuoma, Kati, Hirsilä, Maija, Kivirikko, Kari I., Myllyharju, Johanna
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2010
• Subjects: Alternative splicing; Cancer cells; Hypoxia response; Hypoxia-inducible factor; Hypoxia-inducible factor isoform 3; Hypoxia-inducible factor; Alternative splicing; Hypoxia-inducible factor isoform 3; Hypoxia response; Cancer cells

The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells to hypoxia. HIFs are αβ dimers, the human α subunit having three isoforms. HIF-3α is unique among the HIF-α isoforms in that its gene is subject to extensive alternative splicing. Database analyses have p...