Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling

• Published in: Computational toxicology Vol. 13; p. 100115
• Main Authors: Pendse, Salil N., Efremenko, Alina, Hack, C. Eric, Moreau, Marjory, Mallick, Pankajini, Dzierlenga, Michael, Nicolas, Chantel I., Yoon, Miyoung, Clewell, Harvey J., McMullen, Patrick D.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2020
• Subjects: IVIVE; Monte Carlo; Pharmacokinetics; Source to outcome continuum; Monte Carlo; Source to outcome continuum; Pharmacokinetics; IVIVE

An outstanding challenge in the acceptance of alternatives to animal testing is the systematic incorporation of computational models into decision making pipelines. Fifteen years ago, the US EPA Office of Research and Development's framework for computational toxicology emphasized the need for...