3β-taraxerol of Mangifera indica, a PI3K dependent dual activator of glucose transport and glycogen synthesis in 3T3-L1 adipocytes

• Published in: Biochimica et biophysica acta. General subjects Vol. 1800; no. 3; pp. 359 - 366
• Main Authors: Sangeetha, Kadapakkam Nandabalan, Sujatha, Sundaresan, Muthusamy, Velusamy Shanmuganathan, Anand, Singaravel, Nithya, Nirmal, Velmurugan, Devadasan, Balakrishnan, Arun, Lakshmi, Baddireddi Subhadra
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2010
• Subjects: 3T3-L1 adipocytes; 3β-Taraxerol; Glucose uptake; Glycogen synthesis; GSK3β; Mangifera indica; PI3K; IRTK; MTT-3-(4,5-Dimethylthiazol-2-yl)-2,5; IRS; Glycogen synthesis; DMEM; LDH; Glucose uptake; PI3K; RT-PCR; 2-DOG; GSK3 β; 3T3-L1 adipocytes; WT; 3β-Taraxerol; NIDDM; NBT; PKB; Mangifera indica; EAE; IRβ; pNPP; GS; Gen; GSK3β; NMR; PTP1B; BCIP; GLUT4; GAPDH

The present study focuses on identifying and developing an anti-diabetic molecule from plant sources that would effectively combat insulin resistance through proper channeling of glucose metabolism involving glucose transport and storage. Insulin-stimulated glucose uptake formed the basis for isolat...