Isolation and quantification of flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and impact of CiREE on hypoglycaemic, electron microscopic studies of pancreas in streptozotocin (STZ)-induced diabetic rats

The aim of the study was to isolate and quantify flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and to find the impact of CiREE on hypoglycaemic effect, electron microscopical study of pancreas in streptozotocin (STZ)-induced diabetic rats. Quercetin (Rf- 0.72, 0.794%) and kaempfer...

Full description

Saved in:
Bibliographic Details
Published inBiomedicine & preventive nutrition Vol. 3; no. 3; pp. 285 - 297
Main Authors Kalailingam, Pazhanichamy, Balasubramanian, Kunthavai, Kannaian, Bhuvaneswari, Mohammed, Aashefa Kalandar Naina, Meenakshisundram, Kavitha, Tamilmani, Eevera, Kaliaperumal, Rajendran
Format Journal Article
LanguageEnglish
Published Elsevier Masson SAS 01.07.2013
Subjects
Antidiabetic
Costus igneus
Kaempferol
Kaempferol
Antidiabetic
Costus igneus
Online AccessGet full text

Cover

Abstract The aim of the study was to isolate and quantify flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and to find the impact of CiREE on hypoglycaemic effect, electron microscopical study of pancreas in streptozotocin (STZ)-induced diabetic rats. Quercetin (Rf- 0.72, 0.794%) and kaempferol (Rf- 0.35, 4.2%) were quantified by HPTLC using solvent ratio of Toluene:Ethyl acetate:Acetic acid:Methanol (2:7:0.25:0.25) and Toluene:Ethyl acetate:Methanol:Formic acid (6:3:0.2:0.4) respectively. Quercetin derivative compound was characterized by H1, C13 NMR. The CiREE at a dose of 100, 200mg/kg were orally administered as a single dose per day to diabetes-induced rats for a period of 30 days. The effect of CiREE on blood glucose, plasma insulin, liver glycogen, HbA1c and serum lipid profile (Total cholesterol [TC], Triglyceride [TG], Very low density lipoprotein [VLDL], Low density lipoprotein [LDL], High density lipoprotein [HDL]) were measured, histopathological and electron microscopical studies of pancreas were done in normal and diabetic rats. The results showed that fasting rat's blood glucose, serum TC, TG, LDL, VLDL levels were significantly (P<0.05) increased whereas serum HDL, glycogen and insulin level were significantly (P<0.05) decreased in the diabetic rats, after treatment with CiREE these levels were reverse back to normal. The dosage of 200mg/kg is more effective than that of 100mg/kg. Histopathological and Electron microscopical study of pancreas revealed that number of β-cells and insulin granules are increased in diabetes-induced rats after treatment with CiREE for 30 days. Our investigation thus shows that CiREE has potent antidiabetic and hypolipidemic effects in STZ-induced diabetic rats and these effects were much comparable to that of the standard reference drug glibenclamide.
AbstractList The aim of the study was to isolate and quantify flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and to find the impact of CiREE on hypoglycaemic effect, electron microscopical study of pancreas in streptozotocin (STZ)-induced diabetic rats. Quercetin (Rf- 0.72, 0.794%) and kaempferol (Rf- 0.35, 4.2%) were quantified by HPTLC using solvent ratio of Toluene:Ethyl acetate:Acetic acid:Methanol (2:7:0.25:0.25) and Toluene:Ethyl acetate:Methanol:Formic acid (6:3:0.2:0.4) respectively. Quercetin derivative compound was characterized by H1, C13 NMR. The CiREE at a dose of 100, 200mg/kg were orally administered as a single dose per day to diabetes-induced rats for a period of 30 days. The effect of CiREE on blood glucose, plasma insulin, liver glycogen, HbA1c and serum lipid profile (Total cholesterol [TC], Triglyceride [TG], Very low density lipoprotein [VLDL], Low density lipoprotein [LDL], High density lipoprotein [HDL]) were measured, histopathological and electron microscopical studies of pancreas were done in normal and diabetic rats. The results showed that fasting rat's blood glucose, serum TC, TG, LDL, VLDL levels were significantly (P<0.05) increased whereas serum HDL, glycogen and insulin level were significantly (P<0.05) decreased in the diabetic rats, after treatment with CiREE these levels were reverse back to normal. The dosage of 200mg/kg is more effective than that of 100mg/kg. Histopathological and Electron microscopical study of pancreas revealed that number of β-cells and insulin granules are increased in diabetes-induced rats after treatment with CiREE for 30 days. Our investigation thus shows that CiREE has potent antidiabetic and hypolipidemic effects in STZ-induced diabetic rats and these effects were much comparable to that of the standard reference drug glibenclamide.
Author Kalailingam, Pazhanichamy
Balasubramanian, Kunthavai
Tamilmani, Eevera
Kaliaperumal, Rajendran
Kannaian, Bhuvaneswari
Meenakshisundram, Kavitha
Mohammed, Aashefa Kalandar Naina
Author_xml – sequence: 1
  givenname: Pazhanichamy
  surname: Kalailingam
  fullname: Kalailingam, Pazhanichamy
  organization: Department of Biotechnology, Periyar Maniammai University, Vallam, 613403 Tamilnadu, India
– sequence: 2
  givenname: Kunthavai
  surname: Balasubramanian
  fullname: Balasubramanian, Kunthavai
  organization: Department of Biotechnology, Periyar Maniammai University, Vallam, 613403 Tamilnadu, India
– sequence: 3
  givenname: Bhuvaneswari
  surname: Kannaian
  fullname: Kannaian, Bhuvaneswari
  organization: Department of Biotechnology, Periyar Maniammai University, Vallam, 613403 Tamilnadu, India
– sequence: 4
  givenname: Aashefa Kalandar Naina
  surname: Mohammed
  fullname: Mohammed, Aashefa Kalandar Naina
  organization: Department of Biotechnology, Periyar Maniammai University, Vallam, 613403 Tamilnadu, India
– sequence: 5
  givenname: Kavitha
  surname: Meenakshisundram
  fullname: Meenakshisundram, Kavitha
  organization: Department of Biotechnology, Periyar Maniammai University, Vallam, 613403 Tamilnadu, India
– sequence: 6
  givenname: Eevera
  surname: Tamilmani
  fullname: Tamilmani, Eevera
  organization: Dry land Agricultural Research Station, Tamil Nadu Agricultural University, 630102 Chettinad, India
– sequence: 7
  givenname: Rajendran
  surname: Kaliaperumal
  fullname: Kaliaperumal, Rajendran
  email: nkraj64@yahoo.co.uk
  organization: Department of Biotechnology, Periyar Maniammai University, Vallam, 613403 Tamilnadu, India
BookMark eNqFUcFu1DAQjVCRKKV_wMHHViLBjje7CQcktFqgUiUkKBcu1sQed2eV2MH2Vt3-K_-C0wUJcQBfxvM074393vPixHmHRfFS8EpwsXy9q3rybp-qmgtZcVFxLp4Up3UteNnUsjv54_6sOI9xx_NplrWQ4rT4cRX9ACkrMHCGfd-DS2RJHyFvmR3gzjtPJjIb_MgwbcH5geF9CqDTPLL2Me0jo1uHuYQtPfgR2cWaPm82l4-yNE6_Z2eQZentYfK3w0EDjqRfMRxQp5Dx3AUftZ9IsyxrCOPMm8DpgJC3uAwHnJJ_8Mnr3F58ufl2WZIze42GGYIeUyYHSPFF8dTCEPH8Vz0rvr7f3Kw_ltefPlyt312XOluTytroVveiF1K2rTG95EtoOo4SbWtB69WiAWiEtp1cNt0Cat21qw5Wfd1x09hWnhWLo-789hjQqinQCOGgBFdzSmqnjimpOSXFhcopZdqbv2ia0qPz2Vsa_kd-eyRj_tgdYVBRE7rsAYXspTKe_i3wExIsuHc
CitedBy_id crossref_primary_10_1155_2021_2920530
crossref_primary_10_1002_cbdv_201800365
crossref_primary_10_1111_jam_14783
crossref_primary_10_1017_S1431927615015020
crossref_primary_10_1080_2314808X_2023_2222467
crossref_primary_10_1016_j_jep_2016_09_026
Cites_doi 10.1016/S0378-8741(00)00328-7
10.1248/bpb.28.1431
10.1016/0378-8741(86)90150-9
10.1016/j.jep.2003.12.031
10.1016/S0378-8741(02)00144-7
10.1016/0009-8981(81)90312-0
10.7326/0003-4819-131-4-199908170-00008
10.1016/S0367-326X(03)00163-1
10.1016/S0378-8741(99)00136-1
10.1371/journal.pone.0013463
10.1016/S0140-6736(81)91091-6
10.1016/S1262-3636(07)70125-8
10.1006/phrs.1996.0001
10.1007/BF02867368
10.2337/diacare.18.8.1113
10.1002/(SICI)1096-9136(199712)14:5+3.3.CO;2-I
10.1248/jhs.57.37
10.1016/0168-8227(95)01064-K
10.1056/NEJM197608192950810
10.1016/S0378-8741(02)00366-5
10.1248/cpb.41.1238
10.1016/j.jtemb.2006.06.003
10.4103/0974-7788.64396
10.1016/0378-8741(89)90001-9
10.1016/j.jep.2003.09.034
10.1016/S0378-8741(00)00319-6
10.1016/j.lfs.2004.04.019
ContentType Journal Article
Copyright 2013 Elsevier Masson SAS
Copyright_xml – notice: 2013 Elsevier Masson SAS
DBID AAYXX
CITATION
DOI 10.1016/j.bionut.2013.01.001
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Diet & Clinical Nutrition
EISSN 2210-5239
EndPage 297
ExternalDocumentID 10_1016_j_bionut_2013_01_001
S2210523913000081
GroupedDBID ---
--K
--M
.~1
0R~
1~.
1~5
4.4
4G.
7-5
8P~
AACTN
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAOAW
AAXUO
ABBQC
ABLVK
ABMAC
ABXDB
ABYKQ
ACDAQ
ACGFS
ACJTP
ACRLP
ADBBV
ADEZE
AEBSH
AEKER
AFKWA
AFTJW
AFXBA
AFXIZ
AGHFR
AGUBO
AGYEJ
AIEXJ
AIKHN
AISVY
AITUG
AJBFU
AJOXV
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BKOJK
BLXMC
EBS
EFJIC
EFLBG
EJD
FDB
FIRID
FNPLU
FYGXN
HZ~
J1W
KOM
LCYCR
M41
MO0
N9A
NAHTW
O-L
O9-
OAUVE
P-8
P-9
PC.
Q38
ROL
SDF
SEM
SNG
SSH
SSZ
T5K
AATTM
AAXKI
AAYWO
AAYXX
ABJNI
ABWVN
ACIEU
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFPUW
AGCQF
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
CITATION
ID FETCH-LOGICAL-c221t-2dc8cb1b13388ddb306a590e3ef8facc745aa51cf936594a2c9879a7b290d5f83
IEDL.DBID AIKHN
ISSN 2210-5239
IngestDate Thu Apr 24 22:57:48 EDT 2025
Tue Jul 01 03:59:46 EDT 2025
Fri Feb 23 02:22:02 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Kaempferol
Antidiabetic
Costus igneus
Language English
License https://www.elsevier.com/tdm/userlicense/1.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c221t-2dc8cb1b13388ddb306a590e3ef8facc745aa51cf936594a2c9879a7b290d5f83
PageCount 13
ParticipantIDs crossref_primary_10_1016_j_bionut_2013_01_001
crossref_citationtrail_10_1016_j_bionut_2013_01_001
elsevier_sciencedirect_doi_10_1016_j_bionut_2013_01_001
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate July-September 2013
2013-7-00
PublicationDateYYYYMMDD 2013-07-01
PublicationDate_xml – month: 07
  year: 2013
  text: July-September 2013
PublicationDecade 2010
PublicationTitle Biomedicine & preventive nutrition
PublicationYear 2013
Publisher Elsevier Masson SAS
Publisher_xml – name: Elsevier Masson SAS
References Vats, Yadav, Grover (bib0135) 2004; 90
Andiade-cetto. Ethanopharmacological study of Equisetum myriochaetum schlechtendal and Cecropia obtusifolia bertol. Doctoral thesis, science school, national university of Maxico, 1999;97.
Ko, Choi, Park, Jang, Kim, Park (bib0240) 2005; 28
Hume, Weidemann, Ferber (bib0250) 1979; 62
Chakravarthy, Gupta, Gambhir, Gode (bib0190) 1981; 1
Suba, Murrugesan, Bhaskara, Ghosh, Pal, Subhash (bib0225) 2004; 7
Bolkent, Yanarda, Tabakolu-Ouz, Ozsoy-Sacan (bib0155) 2000; 73
Muller, Schmulling, Eggstein M (bib0095) 1977; 15
Hii, Howell (bib0195) 1984; 101
Carroll, Longley, Joseph (bib0090) 1955; 28
Presenna (bib0080) 2000; 32
Abraira, Colwell, Nuttall, Sawin, Nagel, Comstock (bib0115) 1995; 18
Khosa, Pandacy, Singh (bib0205) 1983; 20
Sharma, Nasir, Prabhu, Murthy, Gev (bib0145) 2003; 85
Li, Zheng, Bukuru, De kimpe (bib0010) 2004; 92
Halim (bib0015) 2003; 18
Noor, Gunasekeran, Manicckam, Vijayalakshmi (bib0160) 2008; 94
Kar, Choudhary, Bandyopadhyay (bib0100) 2003; 84
Basnet, Kadota, Terashima, Shimizu Namba (bib0210) 1983; 41
Stanely, Prince, Menon (bib0235) 2000; 70
Sudhakar Nayak, Pattabiraman (bib0085) 1981; 109
Han, Yuan, Wang, Li (bib0105) 2006; 25
Leng, Lu, Xu (bib0245) 2004; 25
WHO Study Report (bib0020) 1985; 727
Sofowora (bib0060) 1993
DeFronzo (bib0125) 1999; 131
Devi Vishalakshi, Urooj (bib0025) 2008; 46
Bhat, Asuti, Kamat, Sikarwar, Patil (bib0035) 2010; 3
Kripa Krishnan, Vijayalakshmi, Helen (bib0050) 2011; 3
Saraswathi, Lokesh Upadhyay, Venkatakrishnan, Meera, Devi (bib0030) 2010; 2
Gabbay (bib0130) 1976; 95
Harbone (bib0070) 1973
Ivorra, Paya, Villar (bib0220) 1989; 27
Shetty, Parampalli, Bhandarkar, Kotian (bib0045) 2010; 4
Soto, Mena, Luna, Cerbon, Larrieta, Vital (bib0165) 2004; 75
Nuraliev, Avezov (bib0185) 1992; 55
Pazhanichamy, Aiswarya Devi, Jeba Samuel, Priya, Yogha, Manjula (bib0055) 2011; 57
Undie, Akubue (bib0170) 1986; 86
Shetty, Choudhury, Rejeesh, Nair, Kuruvilla, Kotian (bib0040) 2010; 1
Mukund, Rao, Srinivasan, Mamathadevi, Satish (bib0110) 2008; 15
Sharma, Buras, Terashima, Serrano, Massaad, Hu (bib0255) 2010; 5
Ohkubo, Kishikawa, Araki, Miyata, Isami, Motoyoshi (bib0120) 1995; 28
De Sereday, Gonzalez, Giorgini, DeLoredo, Cobenas, Tebone (bib0140) 2004; 30
Desoky, Youssef (bib0215) 1997; 35
Presenna (bib0175) 2000; 32
Sharma, Paghuram, Rao (bib0180) 1990; 44
Trease, Evans (bib0065) 1978
Szkudelski (bib0150) 2001; 50
Amos, Mc Carty, Zimmet (bib0005) 1997; 14
Sarkar, Pranava, Marita (bib0075) 1996; 33
Grover, Vats, Rathi (bib0230) 2000; 73
Sudhakar Nayak (10.1016/j.bionut.2013.01.001_bib0085) 1981; 109
Stanely (10.1016/j.bionut.2013.01.001_bib0235) 2000; 70
Sofowora (10.1016/j.bionut.2013.01.001_bib0060) 1993
Abraira (10.1016/j.bionut.2013.01.001_bib0115) 1995; 18
Noor (10.1016/j.bionut.2013.01.001_bib0160) 2008; 94
Amos (10.1016/j.bionut.2013.01.001_bib0005) 1997; 14
Sharma (10.1016/j.bionut.2013.01.001_bib0180) 1990; 44
Kripa Krishnan (10.1016/j.bionut.2013.01.001_bib0050) 2011; 3
Pazhanichamy (10.1016/j.bionut.2013.01.001_bib0055) 2011; 57
Nuraliev (10.1016/j.bionut.2013.01.001_bib0185) 1992; 55
Vats (10.1016/j.bionut.2013.01.001_bib0135) 2004; 90
Sharma (10.1016/j.bionut.2013.01.001_bib0255) 2010; 5
Basnet (10.1016/j.bionut.2013.01.001_bib0210) 1983; 41
Szkudelski (10.1016/j.bionut.2013.01.001_bib0150) 2001; 50
Bhat (10.1016/j.bionut.2013.01.001_bib0035) 2010; 3
Bolkent (10.1016/j.bionut.2013.01.001_bib0155) 2000; 73
Trease (10.1016/j.bionut.2013.01.001_bib0065) 1978
Gabbay (10.1016/j.bionut.2013.01.001_bib0130) 1976; 95
Sharma (10.1016/j.bionut.2013.01.001_bib0145) 2003; 85
Shetty (10.1016/j.bionut.2013.01.001_bib0040) 2010; 1
Han (10.1016/j.bionut.2013.01.001_bib0105) 2006; 25
Soto (10.1016/j.bionut.2013.01.001_bib0165) 2004; 75
Li (10.1016/j.bionut.2013.01.001_bib0010) 2004; 92
Presenna (10.1016/j.bionut.2013.01.001_bib0080) 2000; 32
Hii (10.1016/j.bionut.2013.01.001_bib0195) 1984; 101
De Sereday (10.1016/j.bionut.2013.01.001_bib0140) 2004; 30
Devi Vishalakshi (10.1016/j.bionut.2013.01.001_bib0025) 2008; 46
WHO Study Report (10.1016/j.bionut.2013.01.001_bib0020) 1985; 727
Shetty (10.1016/j.bionut.2013.01.001_bib0045) 2010; 4
Muller (10.1016/j.bionut.2013.01.001_bib0095) 1977; 15
Ko (10.1016/j.bionut.2013.01.001_bib0240) 2005; 28
Chakravarthy (10.1016/j.bionut.2013.01.001_bib0190) 1981; 1
Halim (10.1016/j.bionut.2013.01.001_bib0015) 2003; 18
Presenna (10.1016/j.bionut.2013.01.001_bib0175) 2000; 32
Sarkar (10.1016/j.bionut.2013.01.001_bib0075) 1996; 33
Desoky (10.1016/j.bionut.2013.01.001_bib0215) 1997; 35
Ivorra (10.1016/j.bionut.2013.01.001_bib0220) 1989; 27
Harbone (10.1016/j.bionut.2013.01.001_bib0070) 1973
Khosa (10.1016/j.bionut.2013.01.001_bib0205) 1983; 20
Undie (10.1016/j.bionut.2013.01.001_bib0170) 1986; 86
10.1016/j.bionut.2013.01.001_bib0200
Mukund (10.1016/j.bionut.2013.01.001_bib0110) 2008; 15
Kar (10.1016/j.bionut.2013.01.001_bib0100) 2003; 84
Grover (10.1016/j.bionut.2013.01.001_bib0230) 2000; 73
Suba (10.1016/j.bionut.2013.01.001_bib0225) 2004; 7
Saraswathi (10.1016/j.bionut.2013.01.001_bib0030) 2010; 2
DeFronzo (10.1016/j.bionut.2013.01.001_bib0125) 1999; 131
Ohkubo (10.1016/j.bionut.2013.01.001_bib0120) 1995; 28
Leng (10.1016/j.bionut.2013.01.001_bib0245) 2004; 25
Carroll (10.1016/j.bionut.2013.01.001_bib0090) 1955; 28
Hume (10.1016/j.bionut.2013.01.001_bib0250) 1979; 62
References_xml – volume: 92
  start-page: 1
  year: 2004
  end-page: 21
  ident: bib0010
  article-title: Natural medicine used in the traditional Chinese medical system for the therapy of diabetes
  publication-title: J Ethanopharmacol
– volume: 41
  start-page: 1238
  year: 1983
  end-page: 1243
  ident: bib0210
  article-title: Two new 2-arylbenzofuran derivatives from hypoglycemic activity bearing fraction of
  publication-title: Chem Pharm Bull
– volume: 90
  start-page: 155
  year: 2004
  end-page: 160
  ident: bib0135
  article-title: Ethanolic extract of
  publication-title: J Ethnopharmacol
– volume: 35
  start-page: 257
  year: 1997
  end-page: 261
  ident: bib0215
  article-title: Hypoglycemic effect of Sterculia rupestris and a comparative study of its flavonoids with
  publication-title: Bull Fac Pharm
– volume: 25
  start-page: 496
  year: 2004
  end-page: 502
  ident: bib0245
  article-title: Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion
  publication-title: Acta Pharm Sinic
– volume: 109
  start-page: 267
  year: 1981
  end-page: 274
  ident: bib0085
  article-title: A new colorimetric method for estimation of glycosylated haemoglobin
  publication-title: Clin Chem Acta
– volume: 18
  start-page: 1113
  year: 1995
  end-page: 1123
  ident: bib0115
  article-title: Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes
  publication-title: Diabetes Care
– volume: 84
  start-page: 105
  year: 2003
  end-page: 108
  ident: bib0100
  article-title: Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats
  publication-title: J Ethnopharmacol
– volume: 25
  start-page: 191
  year: 2006
  end-page: 196
  ident: bib0105
  article-title: Hypoglycemic activity of fermented mushroom of
  publication-title: J Trace Elem Med Biol
– volume: 70
  start-page: 9
  year: 2000
  end-page: 15
  ident: bib0235
  article-title: Hypoglycaemic and other related actions of
  publication-title: J Ethnopharmacol
– volume: 18
  start-page: 54
  year: 2003
  end-page: 63
  ident: bib0015
  article-title: Effect of
  publication-title: J Clin Biochem
– year: 1973
  ident: bib0070
  article-title: Phytochemical methods
– year: 1978
  ident: bib0065
  article-title: Pharmacology
– volume: 15
  start-page: 457
  year: 1977
  end-page: 504
  ident: bib0095
  article-title: A fully enzymatic triglyceride determination
  publication-title: J Clin Chem
– volume: 20
  start-page: 241
  year: 1983
  end-page: 243
  ident: bib0205
  article-title: Experimental studies on
  publication-title: Ind Drugs
– volume: 28
  start-page: 103
  year: 1995
  end-page: 117
  ident: bib0120
  article-title: Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulindependent diabetes mellitus: a randomized prospective 6-year study
  publication-title: Diabetes Res Clin Pract
– volume: 32
  start-page: 34
  year: 2000
  end-page: 36
  ident: bib0175
  article-title: Hypoglycemic effect of fenugreak: a clinical study
  publication-title: Ind J Pharmacol
– volume: 85
  start-page: 201
  year: 2003
  end-page: 206
  ident: bib0145
  article-title: Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of
  publication-title: J Ethnopharmacol
– volume: 95
  start-page: 443
  year: 1976
  end-page: 454
  ident: bib0130
  article-title: Glycosylated hemoglobin and diabetic control
  publication-title: New Eng J Med
– volume: 3
  start-page: 42
  year: 2011
  end-page: 46
  ident: bib0050
  article-title: Beneficial effects of Costus igneus and dose response Studies in streptozotocin-induced diabetic rats
  publication-title: Intern J Curr Pharm Res
– volume: 1
  start-page: 759
  year: 1981
  end-page: 760
  ident: bib0190
  article-title: Pancreatic regeneration in rats by ephicetachin
  publication-title: Lancet
– volume: 57
  start-page: 37
  year: 2011
  end-page: 46
  ident: bib0055
  article-title: The Efficacy of
  publication-title: J Health Sci
– volume: 3
  start-page: 608
  year: 2010
  end-page: 611
  ident: bib0035
  article-title: Antidiabetic activity of insulin plant (
  publication-title: J Pharm Res
– volume: 4
  start-page: 2617
  year: 2010
  end-page: 2621
  ident: bib0045
  article-title: Effect of the insulin plant (
  publication-title: J Clin Diagn Res
– volume: 131
  start-page: 281
  year: 1999
  end-page: 303
  ident: bib0125
  article-title: Pharmacologic therapy for type 2 diabetes mellitus
  publication-title: Ann Intern Med
– volume: 28
  start-page: 1431
  year: 2005
  end-page: 1437
  ident: bib0240
  article-title: Insulin sensitizing and insulinotropic action of berberine from
  publication-title: Biol Pharm Bull
– volume: 1
  start-page: 100
  year: 2010
  end-page: 102
  ident: bib0040
  article-title: Effect of the insulin plant (
  publication-title: Int J Ayurveda Res
– reference: Andiade-cetto. Ethanopharmacological study of Equisetum myriochaetum schlechtendal and Cecropia obtusifolia bertol. Doctoral thesis, science school, national university of Maxico, 1999;97.
– volume: 55
  start-page: 42
  year: 1992
  end-page: 44
  ident: bib0185
  article-title: The efficacy of Qucertin in alloxan diabetes
  publication-title: Eks Klin Farmakol
– volume: 32
  start-page: 34
  year: 2000
  end-page: 36
  ident: bib0080
  article-title: Hypoglycemic effect of fenugreak: a clinical study
  publication-title: Ind J of Pharmacol
– volume: 73
  start-page: 461
  year: 2000
  end-page: 470
  ident: bib0230
  article-title: Antihyperglycemic effects of
  publication-title: J Ethnopharmacol
– volume: 5
  start-page: e13463
  year: 2010
  ident: bib0255
  article-title: Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice
  publication-title: PloS
– volume: 86
  start-page: 133
  year: 1986
  end-page: 134
  ident: bib0170
  article-title: Pharmacological evalution of
  publication-title: J Ethnopharmacol
– volume: 75
  start-page: 2167
  year: 2004
  end-page: 2180
  ident: bib0165
  article-title: Salymarin induces recovery of pancreatic function after alloxan damage in rats
  publication-title: Life Sci
– volume: 46
  start-page: 614
  year: 2008
  end-page: 616
  ident: bib0025
  article-title: Hypoglycemic potential of
  publication-title: Indian J Exp Biol
– volume: 30
  start-page: 335
  year: 2004
  end-page: 339
  ident: bib0140
  article-title: Prevalence of diabetes, obesity, hypertension and hyperlipidemia in the central area of Argentina
  publication-title: Diabetes Metab
– volume: 50
  start-page: 536
  year: 2001
  end-page: 546
  ident: bib0150
  article-title: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
  publication-title: Physiol Res
– volume: 27
  start-page: 243
  year: 1989
  end-page: 275
  ident: bib0220
  article-title: A review of natural products and plants as potential antidiabetic drugs
  publication-title: J Ethnopharmacol
– volume: 2
  start-page: 444
  year: 2010
  end-page: 448
  ident: bib0030
  article-title: Isolation and biological evaluation of steroid from stem of
  publication-title: J Chem Pharm Res
– volume: 73
  start-page: 251
  year: 2000
  end-page: 259
  ident: bib0155
  article-title: Effect of Chard (Beta vulgaris L. Var. Cida) extract on pancreatic B cells in streptozotocin-diabetic rats: a Morphological and Biochemical Study
  publication-title: J Ethanopharmacol
– volume: 727
  start-page: 1
  year: 1985
  end-page: 113
  ident: bib0020
  article-title: Diabetes mellitus
  publication-title: WHO Tech Rep Ser
– volume: 7
  start-page: 1
  year: 2004
  end-page: 4
  ident: bib0225
  article-title: Antidiabetic potential of Barterialupulina extract in rats
  publication-title: Fitoterapia
– volume: 44
  start-page: 301
  year: 1990
  end-page: 306
  ident: bib0180
  article-title: Effect of fenugreak seed on blood glucose and serum lipids in type I diabetic
  publication-title: Eur J Clin Nutr
– volume: 14
  start-page: 81
  year: 1997
  end-page: 85
  ident: bib0005
  article-title: The rising global burden of diabetes and its complications: estimates and projections to the year 2010
  publication-title: Diabet Med
– volume: 15
  start-page: 819
  year: 2008
  end-page: 824
  ident: bib0110
  article-title: Hypoglycemic and hypolipidemic effect of
  publication-title: Pharmacogn Mag
– volume: 28
  start-page: 583
  year: 1955
  end-page: 593
  ident: bib0090
  article-title: The determination of glycogen in liver and muscle by use of anthrone reagent
  publication-title: Depart Biochem
– volume: 101
  start-page: 1
  year: 1984
  end-page: 8
  ident: bib0195
  article-title: Effect of Flavonoids on insulin secretion and ca2+
  publication-title: J Endocrinol
– year: 1993
  ident: bib0060
  article-title: Medicinal plants and Traditional medicine in Africa
– volume: 94
  start-page: 1070
  year: 2008
  end-page: 1076
  ident: bib0160
  article-title: Antidiabetic activity of Aloe vera and histology of organs in streptozotocin-induced diabetic rats
  publication-title: Curr Sci
– volume: 62
  start-page: 1243
  year: 1979
  end-page: 1246
  ident: bib0250
  article-title: Preferential inhibition of quercetine of Mitogenic stimulated thymocyte glucose transport
  publication-title: J Natl Cancer Inst
– volume: 33
  start-page: 1
  year: 1996
  end-page: 4
  ident: bib0075
  article-title: Demonstration of the hypoglycemic action of Momordica charantia in a validated animalmodel of diabetes
  publication-title: Pharmacol Res
– volume: 73
  start-page: 251
  issue: 1–2
  year: 2000
  ident: 10.1016/j.bionut.2013.01.001_bib0155
  article-title: Effect of Chard (Beta vulgaris L. Var. Cida) extract on pancreatic B cells in streptozotocin-diabetic rats: a Morphological and Biochemical Study
  publication-title: J Ethanopharmacol
  doi: 10.1016/S0378-8741(00)00328-7
– volume: 28
  start-page: 1431
  issue: 8
  year: 2005
  ident: 10.1016/j.bionut.2013.01.001_bib0240
  article-title: Insulin sensitizing and insulinotropic action of berberine from Cortidisrhizoma
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.28.1431
– volume: 46
  start-page: 614
  issue: 8
  year: 2008
  ident: 10.1016/j.bionut.2013.01.001_bib0025
  article-title: Hypoglycemic potential of Morus indica. L and Costus igneus. Nak.– A preliminary study
  publication-title: Indian J Exp Biol
– volume: 62
  start-page: 1243
  year: 1979
  ident: 10.1016/j.bionut.2013.01.001_bib0250
  article-title: Preferential inhibition of quercetine of Mitogenic stimulated thymocyte glucose transport
  publication-title: J Natl Cancer Inst
– volume: 86
  start-page: 133
  year: 1986
  ident: 10.1016/j.bionut.2013.01.001_bib0170
  article-title: Pharmacological evalution of Dioscorea dumentorum tuber used in traditional antidiabetic theraphy
  publication-title: J Ethnopharmacol
  doi: 10.1016/0378-8741(86)90150-9
– volume: 92
  start-page: 1
  year: 2004
  ident: 10.1016/j.bionut.2013.01.001_bib0010
  article-title: Natural medicine used in the traditional Chinese medical system for the therapy of diabetes
  publication-title: J Ethanopharmacol
  doi: 10.1016/j.jep.2003.12.031
– volume: 84
  start-page: 105
  year: 2003
  ident: 10.1016/j.bionut.2013.01.001_bib0100
  article-title: Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats
  publication-title: J Ethnopharmacol
  doi: 10.1016/S0378-8741(02)00144-7
– volume: 109
  start-page: 267
  year: 1981
  ident: 10.1016/j.bionut.2013.01.001_bib0085
  article-title: A new colorimetric method for estimation of glycosylated haemoglobin
  publication-title: Clin Chem Acta
  doi: 10.1016/0009-8981(81)90312-0
– volume: 3
  start-page: 42
  issue: 3
  year: 2011
  ident: 10.1016/j.bionut.2013.01.001_bib0050
  article-title: Beneficial effects of Costus igneus and dose response Studies in streptozotocin-induced diabetic rats
  publication-title: Intern J Curr Pharm Res
– volume: 3
  start-page: 608
  issue: 3
  year: 2010
  ident: 10.1016/j.bionut.2013.01.001_bib0035
  article-title: Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
  publication-title: J Pharm Res
– volume: 28
  start-page: 583
  year: 1955
  ident: 10.1016/j.bionut.2013.01.001_bib0090
  article-title: The determination of glycogen in liver and muscle by use of anthrone reagent
  publication-title: Depart Biochem
– ident: 10.1016/j.bionut.2013.01.001_bib0200
– volume: 131
  start-page: 281
  year: 1999
  ident: 10.1016/j.bionut.2013.01.001_bib0125
  article-title: Pharmacologic therapy for type 2 diabetes mellitus
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-131-4-199908170-00008
– volume: 7
  start-page: 1
  year: 2004
  ident: 10.1016/j.bionut.2013.01.001_bib0225
  article-title: Antidiabetic potential of Barterialupulina extract in rats
  publication-title: Fitoterapia
  doi: 10.1016/S0367-326X(03)00163-1
– volume: 70
  start-page: 9
  issue: 1
  year: 2000
  ident: 10.1016/j.bionut.2013.01.001_bib0235
  article-title: Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats
  publication-title: J Ethnopharmacol
  doi: 10.1016/S0378-8741(99)00136-1
– volume: 5
  start-page: e13463
  issue: 10
  year: 2010
  ident: 10.1016/j.bionut.2013.01.001_bib0255
  article-title: Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice
  publication-title: PloS
  doi: 10.1371/journal.pone.0013463
– volume: 1
  start-page: 759
  year: 1981
  ident: 10.1016/j.bionut.2013.01.001_bib0190
  article-title: Pancreatic regeneration in rats by ephicetachin
  publication-title: Lancet
  doi: 10.1016/S0140-6736(81)91091-6
– volume: 15
  start-page: 819
  year: 2008
  ident: 10.1016/j.bionut.2013.01.001_bib0110
  article-title: Hypoglycemic and hypolipidemic effect of Strobilanthes heyneanus in alloxan induced diabetic rats
  publication-title: Pharmacogn Mag
– volume: 30
  start-page: 335
  year: 2004
  ident: 10.1016/j.bionut.2013.01.001_bib0140
  article-title: Prevalence of diabetes, obesity, hypertension and hyperlipidemia in the central area of Argentina
  publication-title: Diabetes Metab
  doi: 10.1016/S1262-3636(07)70125-8
– volume: 33
  start-page: 1
  year: 1996
  ident: 10.1016/j.bionut.2013.01.001_bib0075
  article-title: Demonstration of the hypoglycemic action of Momordica charantia in a validated animalmodel of diabetes
  publication-title: Pharmacol Res
  doi: 10.1006/phrs.1996.0001
– year: 1973
  ident: 10.1016/j.bionut.2013.01.001_bib0070
– volume: 50
  start-page: 536
  year: 2001
  ident: 10.1016/j.bionut.2013.01.001_bib0150
  article-title: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
  publication-title: Physiol Res
– volume: 18
  start-page: 54
  year: 2003
  ident: 10.1016/j.bionut.2013.01.001_bib0015
  article-title: Effect of Coccinia indica and Abroma augusta on glycemia, lipid profile and on indicators of end organ damage in streptozotocin-induced diabetic rats Indian
  publication-title: J Clin Biochem
  doi: 10.1007/BF02867368
– volume: 18
  start-page: 1113
  year: 1995
  ident: 10.1016/j.bionut.2013.01.001_bib0115
  article-title: Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes
  publication-title: Diabetes Care
  doi: 10.2337/diacare.18.8.1113
– volume: 14
  start-page: 81
  year: 1997
  ident: 10.1016/j.bionut.2013.01.001_bib0005
  article-title: The rising global burden of diabetes and its complications: estimates and projections to the year 2010
  publication-title: Diabet Med
  doi: 10.1002/(SICI)1096-9136(199712)14:5+3.3.CO;2-I
– volume: 727
  start-page: 1
  year: 1985
  ident: 10.1016/j.bionut.2013.01.001_bib0020
  article-title: Diabetes mellitus
  publication-title: WHO Tech Rep Ser
– volume: 25
  start-page: 496
  year: 2004
  ident: 10.1016/j.bionut.2013.01.001_bib0245
  article-title: Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion
  publication-title: Acta Pharm Sinic
– volume: 57
  start-page: 37
  issue: 1
  year: 2011
  ident: 10.1016/j.bionut.2013.01.001_bib0055
  article-title: The Efficacy of Costus igneus rhizome on carbohydrate metabolic. Hepatoproductive and antioxidative enzymes in streptozotocin-induced diabetic rats
  publication-title: J Health Sci
  doi: 10.1248/jhs.57.37
– volume: 55
  start-page: 42
  year: 1992
  ident: 10.1016/j.bionut.2013.01.001_bib0185
  article-title: The efficacy of Qucertin in alloxan diabetes
  publication-title: Eks Klin Farmakol
– volume: 32
  start-page: 34
  year: 2000
  ident: 10.1016/j.bionut.2013.01.001_bib0175
  article-title: Hypoglycemic effect of fenugreak: a clinical study
  publication-title: Ind J Pharmacol
– volume: 101
  start-page: 1
  year: 1984
  ident: 10.1016/j.bionut.2013.01.001_bib0195
  article-title: Effect of Flavonoids on insulin secretion and ca2+handling in rats islets of langerhans
  publication-title: J Endocrinol
– volume: 20
  start-page: 241
  year: 1983
  ident: 10.1016/j.bionut.2013.01.001_bib0205
  article-title: Experimental studies on Zizyphus rugosa bark
  publication-title: Ind Drugs
– volume: 28
  start-page: 103
  year: 1995
  ident: 10.1016/j.bionut.2013.01.001_bib0120
  article-title: Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulindependent diabetes mellitus: a randomized prospective 6-year study
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/0168-8227(95)01064-K
– volume: 4
  start-page: 2617
  year: 2010
  ident: 10.1016/j.bionut.2013.01.001_bib0045
  article-title: Effect of the insulin plant (Costus igneus) leaves on blood glucose levels in diabetic patients: a cross sectional study
  publication-title: J Clin Diagn Res
– year: 1993
  ident: 10.1016/j.bionut.2013.01.001_bib0060
– volume: 95
  start-page: 443
  year: 1976
  ident: 10.1016/j.bionut.2013.01.001_bib0130
  article-title: Glycosylated hemoglobin and diabetic control
  publication-title: New Eng J Med
  doi: 10.1056/NEJM197608192950810
– volume: 2
  start-page: 444
  issue: 5
  year: 2010
  ident: 10.1016/j.bionut.2013.01.001_bib0030
  article-title: Isolation and biological evaluation of steroid from stem of Costus igneus
  publication-title: J Chem Pharm Res
– volume: 85
  start-page: 201
  year: 2003
  ident: 10.1016/j.bionut.2013.01.001_bib0145
  article-title: Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits
  publication-title: J Ethnopharmacol
  doi: 10.1016/S0378-8741(02)00366-5
– year: 1978
  ident: 10.1016/j.bionut.2013.01.001_bib0065
– volume: 41
  start-page: 1238
  year: 1983
  ident: 10.1016/j.bionut.2013.01.001_bib0210
  article-title: Two new 2-arylbenzofuran derivatives from hypoglycemic activity bearing fraction of Morus ingignis
  publication-title: Chem Pharm Bull
  doi: 10.1248/cpb.41.1238
– volume: 25
  start-page: 191
  year: 2006
  ident: 10.1016/j.bionut.2013.01.001_bib0105
  article-title: Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium
  publication-title: J Trace Elem Med Biol
  doi: 10.1016/j.jtemb.2006.06.003
– volume: 94
  start-page: 1070
  issue: 8
  year: 2008
  ident: 10.1016/j.bionut.2013.01.001_bib0160
  article-title: Antidiabetic activity of Aloe vera and histology of organs in streptozotocin-induced diabetic rats
  publication-title: Curr Sci
– volume: 15
  start-page: 457
  year: 1977
  ident: 10.1016/j.bionut.2013.01.001_bib0095
  article-title: A fully enzymatic triglyceride determination
  publication-title: J Clin Chem
– volume: 1
  start-page: 100
  issue: 2
  year: 2010
  ident: 10.1016/j.bionut.2013.01.001_bib0040
  article-title: Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia
  publication-title: Int J Ayurveda Res
  doi: 10.4103/0974-7788.64396
– volume: 35
  start-page: 257
  issue: 3
  year: 1997
  ident: 10.1016/j.bionut.2013.01.001_bib0215
  article-title: Hypoglycemic effect of Sterculia rupestris and a comparative study of its flavonoids with Sterculia diversifolia
  publication-title: Bull Fac Pharm
– volume: 27
  start-page: 243
  year: 1989
  ident: 10.1016/j.bionut.2013.01.001_bib0220
  article-title: A review of natural products and plants as potential antidiabetic drugs
  publication-title: J Ethnopharmacol
  doi: 10.1016/0378-8741(89)90001-9
– volume: 90
  start-page: 155
  year: 2004
  ident: 10.1016/j.bionut.2013.01.001_bib0135
  article-title: Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2003.09.034
– volume: 73
  start-page: 461
  year: 2000
  ident: 10.1016/j.bionut.2013.01.001_bib0230
  article-title: Antihyperglycemic effects of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism
  publication-title: J Ethnopharmacol
  doi: 10.1016/S0378-8741(00)00319-6
– volume: 44
  start-page: 301
  issue: 4
  year: 1990
  ident: 10.1016/j.bionut.2013.01.001_bib0180
  article-title: Effect of fenugreak seed on blood glucose and serum lipids in type I diabetic
  publication-title: Eur J Clin Nutr
– volume: 75
  start-page: 2167
  issue: 18
  year: 2004
  ident: 10.1016/j.bionut.2013.01.001_bib0165
  article-title: Salymarin induces recovery of pancreatic function after alloxan damage in rats
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2004.04.019
– volume: 32
  start-page: 34
  year: 2000
  ident: 10.1016/j.bionut.2013.01.001_bib0080
  article-title: Hypoglycemic effect of fenugreak: a clinical study
  publication-title: Ind J of Pharmacol
SSID ssj0000562131
Score 1.9082224
Snippet The aim of the study was to isolate and quantify flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and to find the impact of CiREE on...
SourceID crossref
elsevier
SourceType Enrichment Source
Index Database
Publisher
StartPage 285
SubjectTerms Antidiabetic
Costus igneus
Kaempferol
Title Isolation and quantification of flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and impact of CiREE on hypoglycaemic, electron microscopic studies of pancreas in streptozotocin (STZ)-induced diabetic rats
URI https://dx.doi.org/10.1016/j.bionut.2013.01.001
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZ5XHopfdLtI8yhlATqrt-PY9hu2HRhD3nQ0IvRy4mLI21jbyE99J_2v3TGlkNLoYWejIVGNtLnGY38zQxjrynrn8Iv0ONJzr04yyOPC115OsyFTnVImCG2xSpdnMcfLpKLLTYbY2GIVul0_6DTe23tWqZuNqfrup6ehuitoBtV0A8ZsmzbbBfvUoT27uHxcrG6O2ohGx_0lQlJhFyvYgyi65leAmdgQ7zKIOpTeLoCMX8YqV8Mz9EDdt_tGOFweKmHbEubR2zyvtYdvAGX1rOB1ZhV_zH7cYx46iccuFHwZcMHQtDQZCuoGv7VGlurFii6BDQdn9sGUE9TzBR1mdm227RQXxqNlxsi5l1r2J_VJ_P5QT_sEF7Z96VGwKGvbtf2srmVnAj3b2GssAPXRPqj8JdaQjvwFkkO9RBtWfEpBihkZd3Zb7ZDsBjYPz37dODVRiHwFAznwyiMaG2fsPOj-dls4bkqDp7E6e68UMlcikCQM5wrJdBH4Unh60hXecWlzOKE8ySQVRGlSRHzUBZ5VvBMhIWvkiqPnrIdY41-xiBQQSIL35eRFHGscS_DQy78UHKZVtJPJywal62ULsU5VdpoypHL9rkcFrukxS79gCh9E-bdSa2HFB__6J-NiCh_g2qJVuivks__W_IFuxf2dTiIJ_yS7XQ3G_0Kd0Od2GPb774Hew7zdF2efFz-BMSfEPk
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKOcCl4imW8pgDQq1E2MR5H9Gy1RbKHuhWqrhEfqUNSuOlySKVA_-U_8KMk1QgJJA4RbI8edifZzzONzOMvaCsfxpXoCfiTHhRmoWekKb0DM-kSQwnzBDbYpksTqJ3p_HpFpuNsTBEqxx0f6_TnbYeWqbDaE7XVTU95uitoBuV0w8Zsmw32M0Ily-tztffg-uDFrLwgatLSALkeOVjCJ3jeUn8_g2xKoPQJfAcysP8YaJ-MTsHd9jOsF-EN_0r3WVbprnHJm8r08FLGJJ61rAcc-rfZz8OEU1uuEE0Gr5sRE8H6ptsCWUtvtrGVroFii0BQ4fntgbU0hQxRV1mtu02LVRnjcHLJdHyLgzszaqP8_m-u20fXOn6UiPgrc-v1vasvlKC6PavYKyvAxdE-aPgl0pB27MWSQ61EG1Y8SkNUMDKurPfbIdQaWDvePVp36sajbDT0J8OozBitX3ATg7mq9nCG2o4eAqHu_O4VpmSgSRXONNaooci4tw3oSmzUiiVRrEQcaDKPEziPBJc5Vmai1Ty3NdxmYUP2XZjG_OIQaCDWOW-r0Ilo8jgTkZwIX2uhEpK5ScTFo7TVqghwTnV2aiLkcn2uegnu6DJLvyACH0T5l1LrfsEH__on46IKH4DaoE26K-Sj_9b8jm7tVh9OCqODpfvd9lt7ipyEGP4CdvuLjfmKe6LOvnM4f4niIgQGg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Isolation+and+quantification+of+flavonoids+from+ethanol+extract+of+Costus+igneus+rhizome+%28CiREE%29+and+impact+of+CiREE+on+hypoglycaemic%2C+electron+microscopic+studies+of+pancreas+in+streptozotocin+%28STZ%29-induced+diabetic+rats&rft.jtitle=Biomedicine+%26+preventive+nutrition&rft.au=Kalailingam%2C+Pazhanichamy&rft.au=Balasubramanian%2C+Kunthavai&rft.au=Kannaian%2C+Bhuvaneswari&rft.au=Mohammed%2C+Aashefa+Kalandar+Naina&rft.date=2013-07-01&rft.pub=Elsevier+Masson+SAS&rft.issn=2210-5239&rft.eissn=2210-5239&rft.volume=3&rft.issue=3&rft.spage=285&rft.epage=297&rft_id=info:doi/10.1016%2Fj.bionut.2013.01.001&rft.externalDocID=S2210523913000081
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2210-5239&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2210-5239&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2210-5239&client=summon