Loss-of-function mutations identified in the Helical domain of the G protein α-subunit, Gα2, of Dictyostelium discoideum

• Published in: Biochimica et biophysica acta. General subjects Vol. 1722; no. 3; pp. 262 - 270
• Main Authors: Gundersen, Robert E., You, Jianxin, Rauch, Steven, Farnham, Kate, McCarty, Christopher, Willis, Nicholas, Prince, Alison
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.04.2005
• Subjects: Dictyostelium; G proteins; Signal transduction; Signal transduction; Dictyostelium; G proteins

The guanine nucleotide binding regulatory proteins (G proteins) play essential roles in a wide variety of physiological processes, such as vision, hormone responses, olfaction, immune response, and development. The heterotrimeric G proteins consist of α-, β-, and γ-subunits and act as molecular swit...