Protective Role of MAVS Signaling for Murine Lipopolysaccharide-Induced Acute Kidney Injury

• Published in: ImmunoHorizons Vol. 8; no. 1; pp. 1 - 18
• Main Authors: Tran, Trang Anh Thi, Iwata, Yasunori, Hoang, Linh Thuy, Kitajima, Shinji, Yoneda-Nakagawa, Shiori, Oshima, Megumi, Sakai, Norihiko, Toyama, Tadashi, Yamamura, Yuta, Yamazaki, Hiroka, Hara, Akinori, Shimizu, Miho, Sako, Keisuke, Minami, Taichiro, Yuasa, Takahiro, Horikoshi, Keisuke, Hayashi, Daiki, Kajikawa, Sho, Wada, Takashi
• Format: Journal Article
• Language: English
• Published: United States 01.01.2024
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - metabolism; Animals; Humans; Lipopolysaccharides; Mice; Reactive Oxygen Species - metabolism; Sepsis - metabolism; Toll-Like Receptor 4 - metabolism

Despite treatment advances, acute kidney injury (AKI)-related mortality rates are still high in hospitalized adults, often due to sepsis. Sepsis and AKI could synergistically worsen the outcomes of critically ill patients. TLR4 signaling and mitochondrial antiviral signaling protein (MAVS) signaling...