Plasma cell-free RNA signatures of inflammatory syndromes in children

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 37; p. e2403897121
• Main Authors: Loy, Conor J, Servellita, Venice, Sotomayor-Gonzalez, Alicia, Bliss, Andrew, Lenz, Joan S, Belcher, Emma, Suslovic, Will, Nguyen, Jenny, Williams, Meagan E, Oseguera, Miriam, Gardiner, Michael A, Choi, Jong-Ha, Hsiao, Hui-Mien, Wang, Hao, Kim, Jihoon, Shimizu, Chisato, Tremoulet, Adriana H, Delaney, Meghan, DeBiasi, Roberta L, Rostad, Christina A, Burns, Jane C, Chiu, Charles Y, De Vlaminck, Iwijn
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.09.2024
• Subjects: Adolescent; Bacterial diseases; Bacterial infections; Bacterial Infections - blood; Bacterial Infections - diagnosis; Biological Sciences; Biomarkers - blood; Cell-Free Nucleic Acids - blood; Cell-Free Nucleic Acids - genetics; Child; Child, Preschool; Children; COVID-19 - complications; Diagnosis; Diagnosis, Differential; Differential diagnosis; Disorders; Endothelium; Female; Humans; Infant; Infections; Inflammation - blood; Injury analysis; Learning algorithms; Machine Learning; Male; Mucocutaneous lymph node syndrome; Mucocutaneous Lymph Node Syndrome - blood; Mucocutaneous Lymph Node Syndrome - diagnosis; Mucocutaneous Lymph Node Syndrome - genetics; Multisystem inflammatory syndrome in children; Nervous system; Pediatrics; Respiratory tract; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - diagnosis; Viral infections; Virus Diseases - blood; Virus Diseases - diagnosis; Virus Diseases - genetics; diagnostics; cell-free RNA; machine learning; inflammation; pediatrics

Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell-free RNA (cfRNA) in plasma as an analyt...