Circulating Monocytes Are Predictive and Responsive in Moderate-to-Severe Plaque Psoriasis Subjects Treated with Apremilast - Larson, Emma L.; DeMeo, Dustin P.; Young, Andrew B.; Margevicius, Seunghee; Rutter, Joseph; Davies, Amanda L.; Rohan, Craig A.; Korman, Neil J.; Travers, Jeffrey B.; McCormick, Thomas S.; Cooper, Kevin D. (Journal of investigative dermatology, 2024)
Keywords: Adult; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Apremilast; Biomarker; Biomarkers - blood; Biomarkers - metabolism; Cell Adhesion - drug effects; Female; Flow Cytometry; Humans; Male; Middle Aged; Monocytes; Monocytes - drug effects; Monocytes - metabolism; Phosphodiesterase 4 Inhibitors - pharmacology; Phosphodiesterase 4 Inhibitors - therapeutic use; Psoriasis; Psoriasis - drug therapy; Severity of Illness Index; Thalidomide - analogs & derivatives; Thalidomide - pharmacology; Thalidomide - therapeutic use; Transcriptome; Treatment Outcome; DLQI; Biomarker; Monocytes; Psoriasis; PDE4; Transcriptome; DEG; Apremilast; MPA