MALAT1 regulates mRNA processing through sequence dependent RNA–RNA and RNA–protein interactions

• Published in: Nucleic acids research Vol. 53; no. 15
• Main Authors: Balaji, Adarsh, Hall, Simone, Johnson, Raul, Zhu, Jonathan, Ellis, Lauren, McHugh, Colleen A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 11.08.2025
• Subjects: Acetyltransferases; Alternative Splicing; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; HEK293 Cells; Humans; Protein Binding; RNA and RNA-protein complexes; RNA Precursors - genetics; RNA Precursors - metabolism; RNA Processing, Post-Transcriptional; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-Binding Proteins - metabolism

Messenger RNAs (mRNAs) are subject to multiple layers of gene expression regulation, enabling the production of a large diversity of RNA transcripts and encoded proteins from a smaller number of genes in the human genome. We find that the metastasis-associated lung adenocarcinoma transcript 1 (MALAT...