Visible-light-induced C–H alkylation of pyridine derivatives via 1,2-hydrogen atom transfer

A visible-light-induced radical–radical cross-coupling protocol between hydroxamic acid derivatives and pyridine derivatives for the synthesis of pyridin-2-ylmethanamine derivatives via 1,2-hydrogen atom transfer has been reported. This protocol features metal-free and mild reaction conditions, a br...

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Published inCatalysis science & technology Vol. 15; no. 13; pp. 3940 - 3945
Main Authors Ye, Meiling, Tian, Zeyu, Li, Yuanyuan, Wang, Hang, Huang, Tianle, Yang, Zhongzhen, Wu, Yong
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 30.06.2025
Subjects
Alkylation
Cross coupling
Functional groups
Hydrogen atoms
Pyridines
Radicals
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Summary:A visible-light-induced radical–radical cross-coupling protocol between hydroxamic acid derivatives and pyridine derivatives for the synthesis of pyridin-2-ylmethanamine derivatives via 1,2-hydrogen atom transfer has been reported. This protocol features metal-free and mild reaction conditions, a broad range of substrates, remarkable functional group tolerance and potential application.
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content type line 14
ISSN:2044-4753
2044-4761
DOI:10.1039/D5CY00434A