Protein degradation for drug discovery
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Published in | Drug discovery today. Technologies Vol. 31; pp. 1 - 3 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
01.04.2019
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Subjects | |
Online Access | Get full text |
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Author | Ciulli, Alessio Farnaby, William |
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Author_xml | – sequence: 1 givenname: Alessio surname: Ciulli fullname: Ciulli, Alessio organization: Professor of Chemical & Structural Biology, School of Life Sciences, University of Dundee, Division of Biological Chemistry and Drug Discovery, James Black Centre, Dow Street, Dundee DD1 5EH, United Kingdom – sequence: 2 givenname: William surname: Farnaby fullname: Farnaby, William organization: Professor of Chemical & Structural Biology, School of Life Sciences, University of Dundee, Division of Biological Chemistry and Drug Discovery, James Black Centre, Dow Street, Dundee DD1 5EH, United Kingdom |
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Cites_doi | 10.1016/j.ddtec.2019.02.003 10.1016/j.ddtec.2019.04.001 10.1016/j.ddtec.2019.01.002 10.1016/j.ddtec.2018.11.001 10.1016/j.ddtec.2019.02.002 10.1016/j.ddtec.2019.02.005 10.1016/j.ddtec.2018.12.001 10.1016/j.ddtec.2018.12.002 10.1016/j.ddtec.2019.01.001 10.1016/j.ddtec.2019.02.001 10.1016/j.ddtec.2019.02.004 10.1016/j.ddtec.2018.12.003 |
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References | Chopra (10.1016/j.ddtec.2019.04.002_bib0005) 2019; 31 Daniels (10.1016/j.ddtec.2019.04.002_bib0040) 2019; 31 Naito (10.1016/j.ddtec.2019.04.002_bib0020) 2019; 31 Watt (10.1016/j.ddtec.2019.04.002_bib0035) 2019; 31 Zhang (10.1016/j.ddtec.2019.04.002_bib0030) 2019; 31 Wertz (10.1016/j.ddtec.2019.04.002_bib0060) 2019; 31 Chamberlain (10.1016/j.ddtec.2019.04.002_bib0015) 2019; 31 Grandi (10.1016/j.ddtec.2019.04.002_bib0045) 2019; 31 Yesbolatova (10.1016/j.ddtec.2019.04.002_bib0050) 2019; 31 Mayor-Ruiz (10.1016/j.ddtec.2019.04.002_bib0055) 2019; 31 Pettersson (10.1016/j.ddtec.2019.04.002_bib0010) 2019; 31 Yang (10.1016/j.ddtec.2019.04.002_bib0025) 2019; 31 |
References_xml | – volume: 31 start-page: 109 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0060 article-title: Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.02.003 contributor: fullname: Wertz – volume: 31 start-page: 43 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0025 article-title: Wang S. Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins — A review publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.04.001 contributor: fullname: Yang – volume: 31 start-page: 15 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0010 article-title: PROteolysis TArgeting Chimeras (PROTACs) — Past, present and future publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.01.002 contributor: fullname: Pettersson – volume: 31 start-page: 91 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0050 article-title: Ligand-induced genetic degradation as a tool for target validation publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2018.11.001 contributor: fullname: Yesbolatova – volume: 31 start-page: 5 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0005 article-title: A critical evaluation of the approaches to targeted protein degradation for drug discovery publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.02.002 contributor: fullname: Chopra – volume: 31 start-page: 69 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0035 article-title: Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.02.005 contributor: fullname: Watt – volume: 31 start-page: 61 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0040 article-title: Monitoring and deciphering protein degradation pathways inside cells publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2018.12.001 contributor: fullname: Daniels – volume: 31 start-page: 35 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0020 article-title: SNIPERs—Hijacking IAP activity to induce protein degradation publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2018.12.002 contributor: fullname: Naito – volume: 31 start-page: 53 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0030 article-title: Targeted protein degradation mechanisms publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.01.001 contributor: fullname: Zhang – volume: 31 start-page: 99 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0045 article-title: Advanced proteomics approaches to unravel protein homeostasis publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.02.001 contributor: fullname: Grandi – volume: 31 start-page: 29 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0015 article-title: Cereblon modulators: Low molecular weight inducers of protein degradation publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2019.02.004 contributor: fullname: Chamberlain – volume: 31 start-page: 81 year: 2019 ident: 10.1016/j.ddtec.2019.04.002_bib0055 article-title: Identification and characterization of cancer vulnerabilities via targeted protein degradation publication-title: Drug Discov Today doi: 10.1016/j.ddtec.2018.12.003 contributor: fullname: Mayor-Ruiz |
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SubjectTerms | Drug Discovery - methods Proteins - metabolism Proteolysis - drug effects Small Molecule Libraries - pharmacology Ubiquitination |
Title | Protein degradation for drug discovery |
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