Functional activity of neutrophils and local manifestations of oxidative stress in the mucous membrane of the nasal cavity in the early postoperative period

• Published in: Vestnik otorinolaringologii Vol. 84; no. 2; p. 40
• Main Authors: Gizinger, O A, Korkmazov, A M, Sumerkina, V A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2019
• Subjects: Humans; Lipid Peroxidation; Mucous Membrane - immunology; Mucous Membrane - metabolism; Nasal Cavity; Neutrophils; Oxidative Stress; Postoperative Period; nasal septum; innate immunity; rhinoseptoplasty; antioxidant protection
• DOI: 10.17116/otorino20198402140
• ISSN: 0042-4668

The purpose of the study was to study the factors of antimicrobial, antioxidant defense, variability of nasal secretion lipid peroxidation in patients with curvature of the nasal septum in the early postoperative period. METHODS: microbiological, immunological (assessment of the activity and intensity of phagocytosis, nitrous tetrazolium reduction test) biochemical (study of content diene conjugates, ketodienes, conjugated trines and Schiff bases in the lipid extract of neutrophilic granulocytes), statistical. RESULTS: The dynamics of the content, functional and biochemical activity of neutrophilic granulocytes in nasal washings in individuals who underwent rhinosurgical intervention testifies to the presence of qualitative and quantitative changes in neutrophilic granulocytes of the nasal secretion, recorded in reactions of oxygen-dependent metabolism, free radical oxidation and antioxidant protection.