Comprehensive analysis of immune checkpoint molecules profiles phenotype and function of exhausted T cells in enzootic bovine leukosis

• Published in: The Journal of immunology (1950)
• Main Authors: Nakamura, Hayato, Konnai, Satoru, Okagawa, Tomohiro, Maekawa, Naoya, Tiyamanee, Wisa, Ikehata, Mari, Matsubara, Koume, Watari, Kei, Kamitani, Kana, Saito, Maya, Kato, Yukinari, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: England 27.05.2025
• Subjects: tumor immunity; viral; T cells; large animals; immunodeficiency diseases

Bovine leukemia virus (BLV) causes enzootic bovine leukosis (EBL), a B-cell lymphoma in cattle. Previous studies have demonstrated that T cells of BLV-infected cattle show increased expression of immune checkpoint molecules, including programmed death-1 (PD-1), lymphocyte-activation gene-3 (LAG-3),...