The abasic site as a challenge to DNA polymerase

• Published in: Journal of molecular biology Vol. 213; no. 2; pp. 303 - 314
• Main Authors: Cuniasse, Ph, Fazakerley, G.V., Guschlbauer, W., Kaplan, B.E., Sowers, L.C.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.05.1990

An abasic site in DNA creates a strong block to DNA polymerase and is a mutagenic base lesion. In this study, we present structural and dynamic properties of duplex oligodeoxynucleotides containing G, C and T opposite a model abasic site studied by one and two-dimensional nuclear magnetic resonance...