Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes

• Published in: Experimental gerontology Vol. 194; p. 112505
• Main Authors: Liu, Yi, Wang, Qian, Zhao, Yuhui, Liu, Liu, Hu, Jingxi, Qiao, Yao, Chen, Jinyi, Qin, Chao
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2024; Elsevier
• Subjects: Bayesian colocalization; Genome-wide association studies; Mendelian randomization; Multiple sclerosis; Proteome-wide association studies; Multiple sclerosis; Genome-wide association studies; GWAS; FUSION; MR; MS; IVs; CNS; Mendelian randomization; pQTL; TWAS; Proteome-wide association studies; Bayesian colocalization; SNPs; DGIdb; PWAS

Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering the mechanisms by which these loci influence the target traits. Here, we employed an integrative analytical pipeline to efficiently transform genetic...