Tailored biomimetic hydrogel based on a photopolymerised DMP1/MCF/gelatin hybrid system for calvarial bone regeneration

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 6; no. 3; pp. 414 - 427
• Main Authors: Lin, Shuxian, Cao, Lingyan, Wang, Qian, Du, Jiahui, Jiao, Delong, Duan, Shengzhong, Wu, Jiannan, Gan, Qi, Jiang, Xinquan
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.01.2018
• Subjects: Alkaline phosphatase; Biocompatibility; Biomarkers; Biomedical materials; Biomimetic materials; Biomimetics; Bone growth; Bone marrow; Bone matrix; Cbfa-1 protein; Dentin; Dmp1 protein; Embedded systems; Extracellular matrix; Gelatin; Hybrid systems; Hydrogels; In vivo methods and tests; Kinetics; Mineralization; Nodules; Osteogenesis; Pore size; Pore size distribution; Porosity; Regeneration; Regeneration (physiology); Silica; Silicon dioxide; Size distribution; Stem cell transplantation; Stem cells; Structural hierarchy; Synergistic effect

Searching for effective osteoinduction factors with higher specificity and biosafety for the preparation of biomimetic materials, which mimic the natural bone extracellular matrix (ECM), seems to be an optimum strategy for achieving ideal bone regeneration. Dentin matrix protein 1 (DMP1) seems to be...