Incorporation of small extracellular vesicles in PEG/HA-Bio-Oss hydrogel composite scaffold for bone regeneration

• Published in: Biomedical materials (Bristol) Vol. 19; no. 6; pp. 65014 - 65022
• Main Authors: Zheng, Wenlong, Zhu, Zhanchi, Hong, Jing, Wang, Hao, Cui, Leisha, Zhai, Yuanxin, Li, Jiawei, Wang, Chen, Wang, Zhaojun, Xu, Lunshan, Hao, Ying, Cheng, Guosheng, Ma, Sancheng
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.11.2024
• Subjects: Bio-Oss; bone defects; PEG/HA hydrogel; rBMSC; small extracellular vesicles; tissue engineering; rBMSC; bone defects; Bio-Oss; Small extracellular vesicles; PEG/HA hydrogel; Tissue engineering

Stem cell derived small extracellular vesicles (sEVs) have emerged as promising nanomaterials for the repair of bone defects. However, low retention of sEVs affects their therapeutic effects. Clinically used natural substitute Bio-Oss bone powder lack high compactibility and efficient osteo-inductiv...