Metabolism in vitro of testosterone (T) to 17β-hydroxy-5α-androstane-3-one (DHT) and 5α-androstane-3α,17β-diol (3α) by the 800 g supernatant fraction of ileum from rats
The 800 g supernatant fraction of ileum from rats was incubated with testosterone and production of 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol measured. No difference in this production could be determined between ileum from mature female and mature male animals. Ileum from immatu...
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| Published in | Journal of steroid biochemistry Vol. 19; no. 1; pp. 683 - 686 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
1983
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| Abstract | The 800
g supernatant fraction of ileum from rats was incubated with testosterone and production of 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol measured. No difference in this production could be determined between ileum from mature female and mature male animals. Ileum from immature rats staying with their mothers from day 12 to day 21 showed increased 5α-reduction of testosterone on days 15, 17 and 21. Ileal metabolism to 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol was increased in immature animals on day 25 of extrauterine life when consuming rat chow and water
ad libitum from day 21. This increase could not be demonstrated on day 28. Immature and mature animals treated either with long-acting ACTH or dexamethasone showed increased ileal conversion of testosterone to the two 5α-reduced metabolites determined. Ileum from mature male rats injected, subcutaneously, with arabinosylcytosine every 8th h for 2 days exhibited increased metabolism of testosterone to 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol from the 1st to the 6th day after the last injection of arabinosylcytosine. Different aspects of intestinal metabolism of testosterone are discussed. |
|---|---|
| AbstractList | The 800
g supernatant fraction of ileum from rats was incubated with testosterone and production of 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol measured. No difference in this production could be determined between ileum from mature female and mature male animals. Ileum from immature rats staying with their mothers from day 12 to day 21 showed increased 5α-reduction of testosterone on days 15, 17 and 21. Ileal metabolism to 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol was increased in immature animals on day 25 of extrauterine life when consuming rat chow and water
ad libitum from day 21. This increase could not be demonstrated on day 28. Immature and mature animals treated either with long-acting ACTH or dexamethasone showed increased ileal conversion of testosterone to the two 5α-reduced metabolites determined. Ileum from mature male rats injected, subcutaneously, with arabinosylcytosine every 8th h for 2 days exhibited increased metabolism of testosterone to 17β-hydroxy-5α-androstane-3-one and 5α-androstane-3α,17β-diol from the 1st to the 6th day after the last injection of arabinosylcytosine. Different aspects of intestinal metabolism of testosterone are discussed. |
| Author | Lofthus, Ragnhild Stenstad, Per Eik-Nes, Kristen B. |
| Author_xml | – sequence: 1 givenname: Kristen B. surname: Eik-Nes fullname: Eik-Nes, Kristen B. – sequence: 2 givenname: Per surname: Stenstad fullname: Stenstad, Per – sequence: 3 givenname: Ragnhild surname: Lofthus fullname: Lofthus, Ragnhild |
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| Cites_doi | 10.1677/joe.0.0180056 10.1016/0005-2760(81)90203-4 10.1111/j.1748-1716.1978.tb06085.x 10.1136/gut.23.3.226 10.1126/science.6774420 10.1016/0022-4731(82)90633-1 10.1016/S0021-9673(00)86423-7 10.1038/206300a0 10.1016/0303-7207(77)90003-X 10.1677/joe.0.0400485 10.1016/0016-6480(81)90307-5 10.1677/joe.0.0520161 10.1113/jphysiol.1973.sp010160 10.1016/0016-5085(81)90657-0 10.1016/0012-1606(75)90270-5 10.1016/0012-1606(75)90271-7 |
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| References | Henningson, Persson, Rosengren (BIB17) 1978; 102 Farthing, Vinson, Edwards, Dawson (BIB22) 1982 Stenstad, Østgaard, Eik-Nes (BIB4) 1977; 8 Wright, Morley, Appleton (BIB23) 1972 Halliday (BIB11) 1959; 18 Daniels, Hardy, Malinowska, Nathanielsz (BIB12) 1973; 229 Yeh, Moog (BIB14) 1975; 47 Pirke, Doerr, Sintermann, Vogt (BIB18) 1977; 86 Marnane, Tai, Decker, Boedeker, Charney, Donowitz (BIB9) 1981; 81 Puhvel, Sakamoto (BIB16) 1980; 74 Lenaz, Sternberg, Philips (BIB21) 1969; 29 Koldovsky, Jirsova, Heringova (BIB13) 1965; 206 Crane (BIB20) 1968; Vol. 5 Harri, Nienstedt, Hariala (BIB6) 1970; 43 Yeh, Florence (BIB10) 1975; 47 Stenstad, Eik-Nes (BIB1) 1981; 663 Resko, Feeder, Goy (BIB19) 1968; 40 Lentze, Moxey, Trier (BIB8) 1979; 13 Sunde, Stenstad, Eik-Nes (BIB3) 1979; 175 Stenstad, Eik-Nes (BIB2) 1982; 17 Verjans, Eik-Nes (BIB5) 1976; 83 Nienstedt, Nienstedt, Mannistø (BIB7) 1981; 43 Luk, Marton, Baylin (BIB15) 1980; 210 Yeh (10.1016/0022-4731(83)90235-2_BIB10) 1975; 47 Resko (10.1016/0022-4731(83)90235-2_BIB19) 1968; 40 Luk (10.1016/0022-4731(83)90235-2_BIB15) 1980; 210 Farthing (10.1016/0022-4731(83)90235-2_BIB22) 1982 Henningson (10.1016/0022-4731(83)90235-2_BIB17) 1978; 102 Nienstedt (10.1016/0022-4731(83)90235-2_BIB7) 1981; 43 Pirke (10.1016/0022-4731(83)90235-2_BIB18) 1977; 86 Stenstad (10.1016/0022-4731(83)90235-2_BIB4) 1977; 8 Wright (10.1016/0022-4731(83)90235-2_BIB23) 1972 Crane (10.1016/0022-4731(83)90235-2_BIB20) 1968; Vol. 5 Stenstad (10.1016/0022-4731(83)90235-2_BIB2) 1982; 17 Puhvel (10.1016/0022-4731(83)90235-2_BIB16) 1980; 74 Koldovsky (10.1016/0022-4731(83)90235-2_BIB13) 1965; 206 Lentze (10.1016/0022-4731(83)90235-2_BIB8) 1979; 13 Daniels (10.1016/0022-4731(83)90235-2_BIB12) 1973; 229 Yeh (10.1016/0022-4731(83)90235-2_BIB14) 1975; 47 Lenaz (10.1016/0022-4731(83)90235-2_BIB21) 1969; 29 Halliday (10.1016/0022-4731(83)90235-2_BIB11) 1959; 18 Marnane (10.1016/0022-4731(83)90235-2_BIB9) 1981; 81 Stenstad (10.1016/0022-4731(83)90235-2_BIB1) 1981; 663 Sunde (10.1016/0022-4731(83)90235-2_BIB3) 1979; 175 Harri (10.1016/0022-4731(83)90235-2_BIB6) 1970; 43 Verjans (10.1016/0022-4731(83)90235-2_BIB5) 1976; 83 |
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Endocr. doi: 10.1677/joe.0.0520161 contributor: fullname: Wright – volume: 229 start-page: 681 year: 1973 ident: 10.1016/0022-4731(83)90235-2_BIB12 article-title: The influence of exogenous steroids on macromolecule uptake by the small intestine of the newborn rat publication-title: J. Physiol. doi: 10.1113/jphysiol.1973.sp010160 contributor: fullname: Daniels – volume: 81 start-page: 90 year: 1981 ident: 10.1016/0022-4731(83)90235-2_BIB9 article-title: Methylprednisolone stimulation of guanylate cyclase activity in rat small intestinal mucosa: possible role in electrolyte transport publication-title: Gastroenterology doi: 10.1016/0016-5085(81)90657-0 contributor: fullname: Marnane – volume: 47 start-page: 156 year: 1975 ident: 10.1016/0022-4731(83)90235-2_BIB10 article-title: Development of the small intestine in the hypophysectomized rat. I. Growth, histology, and activity of alkaline phosphatase, maltase and sucrase publication-title: Devel. Biol. doi: 10.1016/0012-1606(75)90270-5 contributor: fullname: Yeh – volume: Vol. 5 start-page: 2535 year: 1968 ident: 10.1016/0022-4731(83)90235-2_BIB20 article-title: The alimentary canal contributor: fullname: Crane – volume: 47 start-page: 173 year: 1975 ident: 10.1016/0022-4731(83)90235-2_BIB14 article-title: Development of the small intestine in the hypophysectomized rat. II. The influence of cortisone, thyroxine, growth hormone, and prolactin publication-title: Devel. Biol. doi: 10.1016/0012-1606(75)90271-7 contributor: fullname: Yeh – volume: 29 start-page: 1790 year: 1969 ident: 10.1016/0022-4731(83)90235-2_BIB21 article-title: Cytotoxic effects of 1-β-d-arabinoforanosyl-5-fluorocytosine and 1-β-d-arabinofuranosylcytosine in proliferating tissue in mice publication-title: Cancer Res. contributor: fullname: Lenaz |
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