Generation of tumors in transgenic mice expressing the SV40 T antigen under the control of ovarian-specific promoter 1

• Published in: Journal of the Society for Gynecologic Investigation Vol. 10; no. 4; p. 244
• Main Authors: Garson, Kenneth, Macdonald, Elizabeth, Dubé, Manon, Bao, Rudi, Hamilton, Thomas C, Vanderhyden, Barbara C
• Format: Journal Article
• Language: English
• Published: United States 01.05.2003
• Subjects: Animals; Antigens, Viral, Tumor - genetics; Antigens, Viral, Tumor - physiology; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Immunohistochemistry; Lac Operon - physiology; Male; Mice; Mice, Transgenic; Nucleic Acid Hybridization; Ovarian Neoplasms - genetics; Promoter Regions, Genetic - genetics; RNA, Messenger - chemistry; RNA, Messenger - genetics; Simian virus 40 - genetics; Simian virus 40 - physiology; Transcription, Genetic

The ovarian-specific promoter, OSP-1, which was cloned from the transcript of a rat retrovirus-like element specifically expressed in ovarian tissue, was tested for its ability to drive ovary-specific transcription in transgenic mice. Transgenic mice were generated with the lacZ reporter gene (OSP-l...