Comparison of Immune Response in Mice Immunized with Recombinant PreS2/S-C18-27 Protein Derived from Hepatitis B Virus with Commercial Vaccine

• Published in: Iranian journal of pathology Vol. 17; no. 4; pp. 448 - 460
• Main Authors: Gholami Parizad, Elaheh, Imani Fooladi, Abbas Ali, Sedighian, Hamid, Behzadi, Elham, Valizadeh, Azar, Khosravi, Afra
• Format: Journal Article
• Language: English
• Published: Iran 2022
• Subjects: Hepatitis B Core Antigen; preS2HBsAg; Hepatitis B Virus; CpG 7909; Hepatitis B Vaccines

The vaccine available to prevent Hepatitis B virus disease is ineffective in 5% of people due to the use of HBsAg as a weak immunogenic factor. In the present study, PreS2/S fused to C18-27 peptide fragment as an effective antigen and is proposed as a promising vaccine candidate compared with the co...