Fe-doped 45S5 bioactive glass compositions impair the metabolic activity and proliferation of metastatic human breast cancer cells in vitro

• Published in: Biomedical materials (Bristol) Vol. 19; no. 5; pp. 55028 - 55042
• Main Authors: Hildenbrand, Nina, Thiele, Wilko, Tripel, Elena, Renkawitz, Tobias, Kermani, Farzad, El-Fiqi, Ahmed, Westhauser, Fabian
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.09.2024
• Subjects: bioactive glass; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Bone Cements - chemistry; Bone Cements - pharmacology; bone metastasis; Bone Neoplasms - metabolism; Bone Neoplasms - secondary; breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Ceramics - chemistry; Ceramics - pharmacology; cytotoxicity; Female; Ferric Compounds - chemistry; ferroptosis; Glass - chemistry; Humans; Iron - chemistry; Materials Testing; Mesenchymal Stem Cells; Particle Size; pathological fracture; Polymethyl Methacrylate - chemistry; breast cancer; bioactive glass; ferroptosis; bone metastasis; pathological fracture; cytotoxicity

Many kinds of human tumors, including breast carcinomas, frequently metastasize to the bone, making it prone to pathologic fractures. Surgical management of bone metastases ranges from the resection of metastases to bone repair. Current surgical methods for the repair of bone defects include the use...