Fe-doped 45S5 bioactive glass compositions impair the metabolic activity and proliferation of metastatic human breast cancer cells in vitro

Many kinds of human tumors, including breast carcinomas, frequently metastasize to the bone, making it prone to pathologic fractures. Surgical management of bone metastases ranges from the resection of metastases to bone repair. Current surgical methods for the repair of bone defects include the use...

Full description

Saved in:
Bibliographic Details
Published inBiomedical materials (Bristol) Vol. 19; no. 5; pp. 55028 - 55042
Main Authors Hildenbrand, Nina, Thiele, Wilko, Tripel, Elena, Renkawitz, Tobias, Kermani, Farzad, El-Fiqi, Ahmed, Westhauser, Fabian
Format Journal Article
LanguageEnglish
Published England IOP Publishing 01.09.2024
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Many kinds of human tumors, including breast carcinomas, frequently metastasize to the bone, making it prone to pathologic fractures. Surgical management of bone metastases ranges from the resection of metastases to bone repair. Current surgical methods for the repair of bone defects include the use of polymethyl methacrylate (PMMA)-based bone cements. A promising alternative material are bioactive glass (BG) particles that in addition to providing physical stability can also induce bone regeneration. Moreover, BGs doped with Fe O may also have a negative impact on tumor cells. Here, we tested the hypothesis that BGs can affect metastatic human breast cancer cells. To this end, we assessed the effects of different BG compositions with and without Fe O on metastatic human MDA-MB-231 breast cancer cells . We found that all BGs tested impaired the viability and proliferation of breast cancer cells in a concentration-dependent manner. The anti-proliferative effects inversely correlated with BG particle size, and were in general less pronounced in mesenchymal stromal cells (MSCs) that served as a control. Moreover, Fe O -doped BGs were more potent inhibitors of tumor cell proliferation and metabolic activity than Fe O -free BG. Our data therefore indicate that BGs can affect human breast cancer cells more strongly than MSCs, and suggest that the presence of Fe O can potentiate anti-proliferative and anti-metabolic effects of BGs. Fe O -doped BGs thus have the potential to be used for the surgical management of metastatic bone lesions, and may in addition to their regenerative properties also allow the local control of bone metastases.
AbstractList Many kinds of human tumors, including breast carcinomas, frequently metastasize to the bone, making it prone to pathologic fractures. Surgical management of bone metastases ranges from the resection of metastases to bone repair. Current surgical methods for the repair of bone defects include the use of polymethyl methacrylate (PMMA)-based bone cements. A promising alternative material are bioactive glass (BG) particles that in addition to providing physical stability can also induce bone regeneration. Moreover, BGs doped with Fe 2 O 3 may also have a negative impact on tumor cells. Here, we tested the hypothesis that BGs can affect metastatic human breast cancer cells. To this end, we assessed the effects of different BG compositions with and without Fe 2 O 3 on metastatic human MDA-MB-231 breast cancer cells in vitro . We found that all BGs tested impaired the viability and proliferation of breast cancer cells in a concentration-dependent manner. The anti-proliferative effects inversely correlated with BG particle size, and were in general less pronounced in mesenchymal stromal cells (MSCs) that served as a control. Moreover, Fe 2 O 3 -doped BGs were more potent inhibitors of tumor cell proliferation and metabolic activity than Fe 2 O 3 -free BG. Our data therefore indicate that BGs can affect human breast cancer cells more strongly than MSCs, and suggest that the presence of Fe 2 O 3 can potentiate anti-proliferative and anti-metabolic effects of BGs. Fe 2 O 3 -doped BGs thus have the potential to be used for the surgical management of metastatic bone lesions, and may in addition to their regenerative properties also allow the local control of bone metastases.
Many kinds of human tumors, including breast carcinomas, frequently metastasize to the bone, making it prone to pathologic fractures. Surgical management of bone metastases ranges from the resection of metastases to bone repair. Current surgical methods for the repair of bone defects include the use of polymethyl methacrylate (PMMA)-based bone cements. A promising alternative material are bioactive glass (BG) particles that in addition to providing physical stability can also induce bone regeneration. Moreover, BGs doped with Fe O may also have a negative impact on tumor cells. Here, we tested the hypothesis that BGs can affect metastatic human breast cancer cells. To this end, we assessed the effects of different BG compositions with and without Fe O on metastatic human MDA-MB-231 breast cancer cells . We found that all BGs tested impaired the viability and proliferation of breast cancer cells in a concentration-dependent manner. The anti-proliferative effects inversely correlated with BG particle size, and were in general less pronounced in mesenchymal stromal cells (MSCs) that served as a control. Moreover, Fe O -doped BGs were more potent inhibitors of tumor cell proliferation and metabolic activity than Fe O -free BG. Our data therefore indicate that BGs can affect human breast cancer cells more strongly than MSCs, and suggest that the presence of Fe O can potentiate anti-proliferative and anti-metabolic effects of BGs. Fe O -doped BGs thus have the potential to be used for the surgical management of metastatic bone lesions, and may in addition to their regenerative properties also allow the local control of bone metastases.
Author Tripel, Elena
El-Fiqi, Ahmed
Hildenbrand, Nina
Renkawitz, Tobias
Kermani, Farzad
Westhauser, Fabian
Thiele, Wilko
Author_xml – sequence: 1
  givenname: Nina
  orcidid: 0000-0002-3988-2018
  surname: Hildenbrand
  fullname: Hildenbrand, Nina
  organization: Heidelberg University Hospital Research Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg, Germany
– sequence: 2
  givenname: Wilko
  orcidid: 0000-0002-8978-4192
  surname: Thiele
  fullname: Thiele, Wilko
  organization: University of Heidelberg Department of Microvascular Biology and Pathobiology, European Center for Angioscience (ECAS), Medical Faculty Mannheism, Mannheim, Germany
– sequence: 3
  givenname: Elena
  surname: Tripel
  fullname: Tripel, Elena
  organization: Heidelberg University Hospital Research Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg, Germany
– sequence: 4
  givenname: Tobias
  surname: Renkawitz
  fullname: Renkawitz, Tobias
  organization: Heidelberg University Hospital Research Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg, Germany
– sequence: 5
  givenname: Farzad
  surname: Kermani
  fullname: Kermani, Farzad
  organization: Mashhad University of Medical Sciences Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad 917794-8564, Iran
– sequence: 6
  givenname: Ahmed
  orcidid: 0000-0002-2344-1728
  surname: El-Fiqi
  fullname: El-Fiqi, Ahmed
  organization: National Research Centre Glass Research Department, Cairo 12622, Egypt
– sequence: 7
  givenname: Fabian
  orcidid: 0000-0001-9948-4209
  surname: Westhauser
  fullname: Westhauser, Fabian
  organization: Heidelberg University Hospital Research Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg, Germany
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39025111$$D View this record in MEDLINE/PubMed
BookMark eNp9kM1OAyEUhYmpsT-6d2XYuXEsFGhnlqaxatLEhZq4I8CApZmBCUxN-gy-tExHuzKuLvdwzknuNwYD550G4BKjW4zyfIoXNM_miL1PRTlnWJ2A0VEaHN8UD8E4xi1CrGCkOANDUqAZwxiPwNdKZ6VvdAkpe2FQWi9Uaz81_KhEjFD5uvHRtta7CG3dCBtgu9Gw1q2QvrIKHuy23UPhStiEpBkdRBeA3hx8sU2rgptdLRyUQScBKuGUDlDpqkq9DqaG4M_BqRFV1Bc_cwLeVvevy8ds_fzwtLxbZ2qG8zYrhJQMS8zoAitDiTayNJRhXcxkSQ2WC0L1PCdJIEUuRPoiRkiljMoLlsQJQH2vCj7GoA1vgq1F2HOMeMeVd-B4B5H3XFPkqo80O1nr8hj4BZkMN73B-oZv_S64dMF_fdd_2GVdc1xwxhFjaJbzpjTkG5GllH4
CODEN BMBUCS
Cites_doi 10.1016/j.bioactmat.2022.02.021
10.3390/cancers12010164.B
10.3390/ma15249082
10.1016/j.pharmthera.2021.107992
10.3390/ijms222413346
10.1038/nrc.2016.44
10.1002/cncr.22991
10.1016/j.apt.2022.103847
10.1038/leu.2016.346
10.1016/j.matlet.2021.129759
10.1038/s41586-019-1170-y
10.1016/j.matlet.2019.05.019
10.1371/journal.pone.0212799
10.1016/j.ccell.2019.04.002
10.1166/jbn.2016.2235
10.3390/biomimetics9010053
10.1016/j.addr.2020.06.025
10.1016/j.bioadv.2023.213521
10.21037/atm.2018.10.30
10.1016/j.mtbio.2021.100100
10.3389/fimmu.2021.614294
10.1016/j.jallcom.2020.155118
10.1002/jbmr.3618
10.1016/j.actbio.2018.11.013
10.1038/nnano.2016.164
10.1016/j.colsurfa.2024.134188
10.1002/adem.200980082
10.4236/njgc.2013.32011
10.1002/jbm.b.31636
10.1155/2022/5653136
10.1177/0885328215621663
10.1016/j.jnoncrysol.2018.09.040
10.1007/BF01402610
10.1038/bjc.2017.356
10.1016/j.actbio.2012.08.023
10.1016/j.mtadv.2020.100066
10.1016/S0030-5898(05)70171-1
10.1016/j.ceramint.2020.08.083
10.1016/j.jtemb.2024.127405
10.1302/0301-620X.84B4.0840521
10.5312/wjo.v15.i3.204
10.1016/j.ceramint.2018.02.122
10.1177/0300060518770958
10.3390/mps3020030
10.1016/j.tranon.2022.101397
10.1038/bjc.1987.13
10.1016/j.biomaterials.2021.120977
10.1111/ijag.12252
10.1007/s10856-016-5732-3
10.5858/2008-132-931-MPOCRF
10.3389/fimmu.2021.693709
ContentType Journal Article
Copyright 2024 IOP Publishing Ltd
2024 IOP Publishing Ltd.
Copyright_xml – notice: 2024 IOP Publishing Ltd
– notice: 2024 IOP Publishing Ltd.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
DOI 10.1088/1748-605X/ad651c
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
DatabaseTitleList CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 1748-605X
ExternalDocumentID 10_1088_1748_605X_ad651c
39025111
bmmad651c
Genre Journal Article
GrantInformation_xml – fundername: Heidelberg University, Faculty of Medicine
GroupedDBID ---
1JI
23N
4.4
53G
5B3
5GY
5VS
5ZH
7.M
7.Q
AAGCD
AAJIO
AAJKP
AATNI
ABHWH
ABJNI
ABQJV
ABVAM
ACAFW
ACGFS
ACHIP
AEFHF
AENEX
AFYNE
AKPSB
ALMA_UNASSIGNED_HOLDINGS
AOAED
ASPBG
ATQHT
AVWKF
AZFZN
CEBXE
CJUJL
CRLBU
CS3
DU5
EBS
EDWGO
EMSAF
EPQRW
EQZZN
F5P
HAK
IJHAN
IOP
IZVLO
KOT
LAP
N5L
N9A
P2P
PJBAE
RIN
RNS
RO9
ROL
RPA
S3P
SY9
UCJ
W28
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
ID FETCH-LOGICAL-c218t-9abb51b15471cf43efbdf451e92bd4f1b734e6831e9398aa4513fabccfc895e93
IEDL.DBID IOP
ISSN 1748-6041
IngestDate Fri Nov 22 03:05:57 EST 2024
Sat Nov 02 12:27:46 EDT 2024
Sun Aug 18 18:10:26 EDT 2024
Tue Aug 20 22:16:38 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords breast cancer
bioactive glass
ferroptosis
bone metastasis
pathological fracture
cytotoxicity
Language English
License This article is available under the terms of the IOP-Standard License.
2024 IOP Publishing Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c218t-9abb51b15471cf43efbdf451e92bd4f1b734e6831e9398aa4513fabccfc895e93
Notes BMM-106319.R2
ORCID 0000-0002-2344-1728
0000-0002-8978-4192
0000-0001-9948-4209
0000-0002-3988-2018
PMID 39025111
PageCount 15
ParticipantIDs pubmed_primary_39025111
crossref_primary_10_1088_1748_605X_ad651c
iop_journals_10_1088_1748_605X_ad651c
PublicationCentury 2000
PublicationDate 2024-09-01
PublicationDateYYYYMMDD 2024-09-01
PublicationDate_xml – month: 09
  year: 2024
  text: 2024-09-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Biomedical materials (Bristol)
PublicationTitleAbbrev BMM
PublicationTitleAlternate Biomed. Mater
PublicationYear 2024
Publisher IOP Publishing
Publisher_xml – name: IOP Publishing
References Hench (bmmad651cbib21) 2013; 03
Bebber (bmmad651cbib5) 2020; 12
El-Fiqi (bmmad651cbib15) 2021; vol 294
Bach (bmmad651cbib3) 1990; 107
Westhauser (bmmad651cbib50) 2019; 14
Jones (bmmad651cbib22) 2013; 9
Borges (bmmad651cbib8) 2022; 15
Fornetti (bmmad651cbib18) 2018; 33
Hage (bmmad651cbib19) 2000; 31
Westhauser (bmmad651cbib48) 2016; 27
Rehder (bmmad651cbib37) 2024; 9
Li (bmmad651cbib29) 2016; 12
Kunisch (bmmad651cbib28) 2023; 153
Ramalingam (bmmad651cbib36) 2020; 834
Kilcup (bmmad651cbib26) 2015; 30
Mulens-Arias (bmmad651cbib33) 2021; 12
Scheurle (bmmad651cbib40) 2024; 83
Westhauser (bmmad651cbib49) 2021; 275
Miola (bmmad651cbib32) 2019; 83
DeRosa (bmmad651cbib13) 2021; 12
Kargozar (bmmad651cbib24) 2019; 251
Wang (bmmad651cbib47) 2019; 569
Jones (bmmad651cbib23) 2016; 7
Scimeca (bmmad651cbib41) 2018; 6
Vernè (bmmad651cbib46) 2010; 12
Arabyazdi (bmmad651cbib1) 2019; 503–504
Coleman (bmmad651cbib10) 1987; 55
Wilkesmann (bmmad651cbib51) 2020; 3
Lindfors (bmmad651cbib31) 2010; 94B
Kim (bmmad651cbib27) 2016; 11
Nogueira (bmmad651cbib35) 2024; 15
Sevimli (bmmad651cbib42) 2018; 46
Kermani (bmmad651cbib25) 2022; 20
Disibio (bmmad651cbib14) 2008; 132
Danewalia (bmmad651cbib12) 2021; 10
El-Meliegy (bmmad651cbib16) 2018; 44
Aras (bmmad651cbib2) 2017; 117
Rust (bmmad651cbib38) 1996; 17
Chen (bmmad651cbib9) 2020; 6
Bakar (bmmad651cbib4) 2022; 2022
Fellenberg (bmmad651cbib17) 2022; 15
Nawaz (bmmad651cbib34) 2020; 46
Hassannia (bmmad651cbib20) 2019; 35
Saad (bmmad651cbib39) 2007; 110
Sui (bmmad651cbib44) 2022; 232
Liao (bmmad651cbib30) 2021; 22
Zhou (bmmad651cbib52) 2024; 694
Böhm (bmmad651cbib6) 2002; 84-B
Bordini (bmmad651cbib7) 2017; 31
Soetaert (bmmad651cbib43) 2020; 154–155
Tadic (bmmad651cbib45) 2022; 33
Croucher (bmmad651cbib11) 2016; 16
References_xml – volume: 15
  start-page: 456
  year: 2022
  ident: bmmad651cbib17
  article-title: Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy
  publication-title: Bioact. Mater.
  doi: 10.1016/j.bioactmat.2022.02.021
  contributor:
    fullname: Fellenberg
– volume: 12
  start-page: 164
  year: 2020
  ident: bmmad651cbib5
  article-title: Ferroptosis in cancer cell biology
  publication-title: Cancers
  doi: 10.3390/cancers12010164.B
  contributor:
    fullname: Bebber
– volume: 15
  start-page: 9082
  year: 2022
  ident: bmmad651cbib8
  article-title: Bioactive glasses as carriers of cancer-targeted drugs: challenges and opportunities in bone cancer treatment
  publication-title: Materials
  doi: 10.3390/ma15249082
  contributor:
    fullname: Borges
– volume: 232
  year: 2022
  ident: bmmad651cbib44
  article-title: Emerging role of ferroptosis in breast cancer: new dawn for overcoming tumor progression
  publication-title: Pharm. Therap.
  doi: 10.1016/j.pharmthera.2021.107992
  contributor:
    fullname: Sui
– volume: 22
  year: 2021
  ident: bmmad651cbib30
  article-title: Synergistic effect of repolarization of M2 to M1 macrophages induced by iron oxide nanoparticles combined with lactate oxidase
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms222413346
  contributor:
    fullname: Liao
– volume: 16
  start-page: 373
  year: 2016
  ident: bmmad651cbib11
  article-title: Bone metastasis: the importance of the neighbourhood
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.44
  contributor:
    fullname: Croucher
– volume: 110
  start-page: 1860
  year: 2007
  ident: bmmad651cbib39
  article-title: Pathologic fractures correlate with reduced survival in patients with malignant bone disease
  publication-title: Cancer
  doi: 10.1002/cncr.22991
  contributor:
    fullname: Saad
– volume: 33
  year: 2022
  ident: bmmad651cbib45
  article-title: Magnetic properties, phase evolution, hollow structure and biomedical application of hematite (α-Fe2O3) and QUAIPH
  publication-title: Adv. Powder Technol.
  doi: 10.1016/j.apt.2022.103847
  contributor:
    fullname: Tadic
– volume: 31
  start-page: 967
  year: 2017
  ident: bmmad651cbib7
  article-title: Induction of iron excess restricts malignant plasma cells expansion and potentiates bortezomib effect in models of multiple myeloma
  publication-title: Leukemia
  doi: 10.1038/leu.2016.346
  contributor:
    fullname: Bordini
– volume: vol 294
  year: 2021
  ident: bmmad651cbib15
  article-title: Iron Ions-releasing Mesoporous Bioactive Glass Ultrasmall Nanoparticles Designed as Ferroptosis-based Bone Cancer Nanotherapeutics: Ultrasonic-coupled Sol–gel Synthesis, Properties and Iron Ions Release
  publication-title: Mater. Lett.
  doi: 10.1016/j.matlet.2021.129759
  contributor:
    fullname: El-Fiqi
– volume: 569
  start-page: 270
  year: 2019
  ident: bmmad651cbib47
  article-title: CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
  publication-title: Nature
  doi: 10.1038/s41586-019-1170-y
  contributor:
    fullname: Wang
– volume: 251
  start-page: 241
  year: 2019
  ident: bmmad651cbib24
  article-title: Mesoporous bioactive glasses (MBGs) in cancer therapy: full of hope and promise
  publication-title: Mater. Lett.
  doi: 10.1016/j.matlet.2019.05.019
  contributor:
    fullname: Kargozar
– volume: 14
  year: 2019
  ident: bmmad651cbib50
  article-title: Osteogenic differentiation of mesenchymal stem cells is enhanced in a 45S5-supplemented β-TCP composite scaffold: an in-vitro comparison of Vitoss and Vitoss BA
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0212799
  contributor:
    fullname: Westhauser
– volume: 35
  start-page: 830
  year: 2019
  ident: bmmad651cbib20
  article-title: Targeting ferroptosis to iron out cancer
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2019.04.002
  contributor:
    fullname: Hassannia
– volume: 12
  start-page: 863
  year: 2016
  ident: bmmad651cbib29
  article-title: Size-dependent mechanism of intracellular localization and cytotoxicity of mono-disperse spherical mesoporous nano-and micron-bioactive glass particles hhs public access
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2016.2235
  contributor:
    fullname: Li
– volume: 9
  start-page: 53
  year: 2024
  ident: bmmad651cbib37
  article-title: The addition of zinc to the ICIE16-Bioactive glass composition enhances osteogenic differentiation and matrix formation of human bone marrow-derived mesenchymal stromal cells
  publication-title: Biomimetics
  doi: 10.3390/biomimetics9010053
  contributor:
    fullname: Rehder
– volume: 154–155
  start-page: 65
  year: 2020
  ident: bmmad651cbib43
  article-title: Cancer therapy with iron oxide nanoparticles: agents of thermal and immune therapies
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.06.025
  contributor:
    fullname: Soetaert
– volume: 153
  year: 2023
  ident: bmmad651cbib28
  article-title: A comparative in vitro and in vivo analysis of the biological properties of the 45S5-, 1393-, and 0106-B1-bioactive glass compositions using human bone marrow-derived stromal cells and a rodent critical size femoral defect model
  publication-title: Biomater. Adv.
  doi: 10.1016/j.bioadv.2023.213521
  contributor:
    fullname: Kunisch
– volume: 6
  start-page: S56
  year: 2018
  ident: bmmad651cbib41
  article-title: New highlight in breast cancer development: the key role of hepcidin and iron metabolism
  publication-title: Ann. Transl. Med.
  doi: 10.21037/atm.2018.10.30
  contributor:
    fullname: Scimeca
– volume: 10
  year: 2021
  ident: bmmad651cbib12
  article-title: Bioactive glasses and glass–ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives
  publication-title: Mater. Today Bio
  doi: 10.1016/j.mtbio.2021.100100
  contributor:
    fullname: Danewalia
– volume: 12
  year: 2021
  ident: bmmad651cbib13
  article-title: The iron curtain: macrophages at the interface of systemic and microenvironmental iron metabolism and immune response in cancer
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.614294
  contributor:
    fullname: DeRosa
– volume: 834
  year: 2020
  ident: bmmad651cbib36
  article-title: Wet chemical mediated hematite α-Fe2O3 nanoparticles synthesis: preparation, characterization and anticancer activity against human metastatic ovarian cancer
  publication-title: J. Alloys Compd.
  doi: 10.1016/j.jallcom.2020.155118
  contributor:
    fullname: Ramalingam
– volume: 33
  start-page: 2099
  year: 2018
  ident: bmmad651cbib18
  article-title: Understanding the bone in cancer metastasis
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.3618
  contributor:
    fullname: Fornetti
– volume: 83
  start-page: 55
  year: 2019
  ident: bmmad651cbib32
  article-title: Glass-ceramics for cancer treatment: so close, or yet so far?
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2018.11.013
  contributor:
    fullname: Miola
– volume: 11
  start-page: 977
  year: 2016
  ident: bmmad651cbib27
  article-title: Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2016.164
  contributor:
    fullname: Kim
– volume: 694
  year: 2024
  ident: bmmad651cbib52
  article-title: Unlocking the potential of iron-containing mesoporous bioactive glasses: orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts
  publication-title: Colloids Surf. A
  doi: 10.1016/j.colsurfa.2024.134188
  contributor:
    fullname: Zhou
– volume: 12
  start-page: B309
  year: 2010
  ident: bmmad651cbib46
  article-title: Surface activation of a ferrimagnetic glass–ceramic for antineoplastic drugs grafting
  publication-title: Adv. Eng. Mater.
  doi: 10.1002/adem.200980082
  contributor:
    fullname: Vernè
– volume: 03
  start-page: 67
  year: 2013
  ident: bmmad651cbib21
  article-title: Chronology of bioactive glass development and clinical applications
  publication-title: New J. Glass Ceram.
  doi: 10.4236/njgc.2013.32011
  contributor:
    fullname: Hench
– volume: 94B
  start-page: 157
  year: 2010
  ident: bmmad651cbib31
  article-title: A prospective randomized 14 year follow-up study of bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors
  publication-title: J. Biomed. Mater. Res. B
  doi: 10.1002/jbm.b.31636
  contributor:
    fullname: Lindfors
– volume: 2022
  start-page: 1
  year: 2022
  ident: bmmad651cbib4
  article-title: Combination of goniothalamin and Sol-Gel-derived bioactive glass 45S5 enhances growth inhibitory activity via apoptosis induction and cell cycle arrest in breast cancer cells MCF-7
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2022/5653136
  contributor:
    fullname: Bakar
– volume: 30
  start-page: 1445
  year: 2015
  ident: bmmad651cbib26
  article-title: Stimulation of apoptotic pathways in liver cancer cells: an alternative perspective on the biocompatibility and the utility of biomedical glasses
  publication-title: J. Biomater. Appl.
  doi: 10.1177/0885328215621663
  contributor:
    fullname: Kilcup
– volume: 503–504
  start-page: 139
  year: 2019
  ident: bmmad651cbib1
  article-title: Synthesis and characterization of CaO-P2O5-SiO2-Li2O-Fe2O3 bioactive glasses: the effect of Li2O-Fe2O3 content on the structure and in-vitro bioactivity
  publication-title: J. Non-Cryst. Solids.
  doi: 10.1016/j.jnoncrysol.2018.09.040
  contributor:
    fullname: Arabyazdi
– volume: 107
  start-page: 37
  year: 1990
  ident: bmmad651cbib3
  article-title: Metastatic spinal cord compression occurrence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression
  publication-title: Acta Neurochir.
  doi: 10.1007/BF01402610
  contributor:
    fullname: Bach
– volume: 117
  start-page: 1583
  year: 2017
  ident: bmmad651cbib2
  article-title: TAMeless traitors: macrophages in cancer progression and metastasis
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2017.356
  contributor:
    fullname: Aras
– volume: 9
  start-page: 4457
  year: 2013
  ident: bmmad651cbib22
  article-title: Review of bioactive glass: from hench to hybrids
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2012.08.023
  contributor:
    fullname: Jones
– volume: 6
  year: 2020
  ident: bmmad651cbib9
  article-title: Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy
  publication-title: Mater. Today. Adv.
  doi: 10.1016/j.mtadv.2020.100066
  contributor:
    fullname: Chen
– volume: 31
  start-page: 515
  year: 2000
  ident: bmmad651cbib19
  article-title: Incidence, location, and diagnostic evaluation of metastatic bone disease
  publication-title: Orthop. Clin. North Am.
  doi: 10.1016/S0030-5898(05)70171-1
  contributor:
    fullname: Hage
– volume: 46
  start-page: 29111
  year: 2020
  ident: bmmad651cbib34
  article-title: Silibinin releasing mesoporous bioactive glass nanoparticles with potential for breast cancer therapy
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2020.08.083
  contributor:
    fullname: Nawaz
– volume: 17
  start-page: 371
  year: 1996
  ident: bmmad651cbib38
  article-title: Bioglass middle ear prosthesis: long-term results
  publication-title: Otol Neurotol
  contributor:
    fullname: Rust
– volume: 83
  year: 2024
  ident: bmmad651cbib40
  article-title: Boric acid and molybdenum trioxide synergistically stimulate osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2024.127405
  contributor:
    fullname: Scheurle
– volume: 84-B
  start-page: 521
  year: 2002
  ident: bmmad651cbib6
  article-title: The surgical treatment of bony metastases of the spine and limbs
  publication-title: J. Bone Joint Surg. Br.
  doi: 10.1302/0301-620X.84B4.0840521
  contributor:
    fullname: Böhm
– volume: 15
  start-page: 204
  year: 2024
  ident: bmmad651cbib35
  article-title: Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine
  publication-title: World J. Orthop.
  doi: 10.5312/wjo.v15.i3.204
  contributor:
    fullname: Nogueira
– volume: 44
  start-page: 9140
  year: 2018
  ident: bmmad651cbib16
  article-title: Novel Fe2O3-doped glass /chitosan scaffolds for bone tissue replacement
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2018.02.122
  contributor:
    fullname: El-Meliegy
– volume: 46
  start-page: 3262
  year: 2018
  ident: bmmad651cbib42
  article-title: Analysis of orthopedic surgery of patients with metastatic bone tumors and pathological fractures
  publication-title: J. Int. Med. Res.
  doi: 10.1177/0300060518770958
  contributor:
    fullname: Sevimli
– volume: 3
  start-page: 1
  year: 2020
  ident: bmmad651cbib51
  article-title: Combined fluorescence-based in vitro assay for the simultaneous detection of cell viability and alkaline phosphatase activity during osteogenic differentiation of osteoblast precursor cells
  publication-title: Methods Protoc.
  doi: 10.3390/mps3020030
  contributor:
    fullname: Wilkesmann
– volume: 20
  year: 2022
  ident: bmmad651cbib25
  article-title: Iron (Fe)-doped mesoporous 45S5 bioactive glasses: implications for cancer therapy
  publication-title: Transl. Oncol.
  doi: 10.1016/j.tranon.2022.101397
  contributor:
    fullname: Kermani
– volume: 55
  start-page: 61
  year: 1987
  ident: bmmad651cbib10
  article-title: The clinical course of bone metastases from breast cancer
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1987.13
  contributor:
    fullname: Coleman
– volume: 275
  year: 2021
  ident: bmmad651cbib49
  article-title: Selective and caspase-independent cytotoxicity of bioactive glasses towards giant cell tumor of bone derived neoplastic stromal cells but not to bone marrow derived stromal cells
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.120977
  contributor:
    fullname: Westhauser
– volume: 7
  start-page: 423
  year: 2016
  ident: bmmad651cbib23
  article-title: Bioglass and bioactive glasses and their impact on healthcare
  publication-title: Int. J. Appl. Glass. Sci.
  doi: 10.1111/ijag.12252
  contributor:
    fullname: Jones
– volume: 27
  start-page: 1
  year: 2016
  ident: bmmad651cbib48
  article-title: Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo
  publication-title: J. Mater. Sci.: Mater. Med.
  doi: 10.1007/s10856-016-5732-3
  contributor:
    fullname: Westhauser
– volume: 132
  start-page: 931
  year: 2008
  ident: bmmad651cbib14
  article-title: Metastatic patterns of cancers results from a large autopsy study
  publication-title: Arch. Pathol. Lab. Med.
  doi: 10.5858/2008-132-931-MPOCRF
  contributor:
    fullname: Disibio
– volume: 12
  year: 2021
  ident: bmmad651cbib33
  article-title: The use of iron oxide nanoparticles to reprogram macrophage responses and the immunological tumor microenvironment
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.693709
  contributor:
    fullname: Mulens-Arias
SSID ssj0059539
Score 2.4179401
Snippet Many kinds of human tumors, including breast carcinomas, frequently metastasize to the bone, making it prone to pathologic fractures. Surgical management of...
SourceID crossref
pubmed
iop
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 55028
SubjectTerms bioactive glass
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Bone Cements - chemistry
Bone Cements - pharmacology
bone metastasis
Bone Neoplasms - metabolism
Bone Neoplasms - secondary
breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Ceramics - chemistry
Ceramics - pharmacology
cytotoxicity
Female
Ferric Compounds - chemistry
ferroptosis
Glass - chemistry
Humans
Iron - chemistry
Materials Testing
Mesenchymal Stem Cells
Particle Size
pathological fracture
Polymethyl Methacrylate - chemistry
Title Fe-doped 45S5 bioactive glass compositions impair the metabolic activity and proliferation of metastatic human breast cancer cells in vitro
URI https://iopscience.iop.org/article/10.1088/1748-605X/ad651c
https://www.ncbi.nlm.nih.gov/pubmed/39025111
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbacoFDebfLS3OAA4dscWI7tjghxKog8ZCg0h6QLD-lFWwSbdMLf6F_umM7W9EKIcQtckZ2PJ7YnzXfzBDyPIg6V4yuELrWFfOMV8aJ5OQVrWeudZGlAOePn8TxCfuw5Msd8voyFqYfpq1_jo8lUXBR4USIk0eIoWWFKHx5ZLzg1O2SG42UIvH53n_-st2GueK5jNgkzejko_xTD1fOpF0c9xrGzGfN4jb5vv3KQjH5MT8b7dz9upbA8T-ncYfsTxgU3hTRu2QndPfIrd8yE94n54tQ-X4IHhj_ysGuepM3RshoGxIRfcv2ghRoudoAIklYhxGN6ufKQRZHhA-m8zCk0kAxFGODPma5FMqEgrlIINjEjR_BJRvcQPImYL8dYA-b_gE5Wbz79va4muo2VA4Bw1gpYy2nFsFZS3GtmxCtj4zToGrrWaS2bVgQssGGRklj8FUTjXUuOqk4Nj4ke13fhUMCXine0hhbaSxrHDeJGyeFqIMJtXFuRl5uV04PJT2Hzm51KXVSsE4K1kXBM_IC10JP_-jpX-TgipxdrzVVmutXeJurpR58nJGDYh-XgzYqX9boo38c5DG5WSM8Kmy1J2Rv3JyFpwhvRvssm_EFxTP1HA
link.rule.ids 314,780,784,27924,27925,38865,53841
linkProvider IOP Publishing
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZokRA9UN5dymMOcOCQ3TqxE_uICquWR6kElfZm_JRWsEm0pJf-Bf40YzuLaIUQErfImdjOzNj-rHkR8tzXZaoYXSB0LQvmGC-0raORt24cs40NLAY4fzipj87Y2wVfjHVOUyxM149b_xQfc6LgzMLRIU7MEEOLAlH4YqZdzamd9S5skeu4cllcmccfTzdbMZc8lRIbv2B0tFP-qZdL59IWjn0FZ6bzZr5Lvmxmmt1Mvk7PBzO1F1eSOP7Hr9wmt0YsCq8y-R1yzbd3yc5vGQrvkR9zX7iu9w4Y_8TBLDudNkhIqBuiQ_rG6wtiwOVyDYgoYeUHVK5vSwuJHJE-6NZBH0sEBZ-VDrqQ6GJIExKmYoFgoo_8ADbq4hqiVQH7bQF7WHf3ydn8zefDo2Ks31BYBA5DIbUxnBoEaQ1FmVc-GBcYp16WxrFATVMxX4sKGyoptMZXVdDG2mCF5Nj4gGy3Xev3CDgpeUNDaIQ2rLJcRx85Udel177U1k7Iy430VJ_TdKhkXhdCRSaryGSVmTwhL1Aealyr3_9CB5fozGqlqFRcHeCtrhQKZTUhD7OO_Bq0kunSRh_94yDPyI3T13P1_vjk3T65WSJiyg5sj8n2sD73TxDxDOZp0uqfNpX6ew
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fe-doped+45S5+bioactive+glass+compositions+impair+the+metabolic+activity+and+proliferation+of+metastatic+human+breast+cancer+cells+in+vitro&rft.jtitle=Biomedical+materials+%28Bristol%29&rft.au=Hildenbrand%2C+Nina&rft.au=Thiele%2C+Wilko&rft.au=Tripel%2C+Elena&rft.au=Renkawitz%2C+Tobias&rft.date=2024-09-01&rft.eissn=1748-605X&rft.volume=19&rft.issue=5&rft_id=info:doi/10.1088%2F1748-605X%2Fad651c&rft_id=info%3Apmid%2F39025111&rft.externalDocID=39025111
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1748-6041&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1748-6041&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1748-6041&client=summon