Treating neuropsychiatric disorders with PDE10A inhibitors

• Published in: Drug discovery today. Therapeutic strategies Vol. 3; no. 4; pp. 527 - 532
• Main Authors: Siuciak, Judith A., Strick, Christine A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2006

Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of the striatum. This article provides a brief overview of the characterization, localization and function of this enzyme, the currently available...