A Comparison of mRNA Expression of Dopamine Receptors, Tyrosine Hydroxylase, and Dopamine Transporter in the Mesolimbic System of Rats with Different Levels of Alcohol Consumption

• Published in: Neurochemical journal Vol. 13; no. 2; pp. 137 - 144
• Main Authors: Anokhin, P. K., Razumkina, E. V., Shamakina, I. Yu
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.04.2019
• Subjects: Biomedical and Life Sciences; Biomedicine; Experimental Articles; Neurosciences; alcohol; mRNA; midbrain; striatum; dopamine; gene expression

Despite numerous studies, there is still no clear idea on the fine mechanisms of dysfunction of the brain dopamine system during the formation of alcohol dependence. In this work, we studied the expression of genes that encode tyrosine hydroxylase (TH), a key enzyme of dopamine synthesis, dopamine t...