RETRACTED: A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells

• Published in: Science translational medicine Vol. 13; no. 592
• Main Authors: Mukherjee, Joydeep, Pandita, Ajay, Kamalakar, Chatla, Johannessen, Tor-Christian, Ohba, Shigeo, Tang, Yongjian, Dalle-Ore, Cecilia L, Bjerkvig, Rolf, Pieper, Russell O
• Format: Journal Article
• Language: English
• Published: United States 05.05.2021
• Subjects: DNA; DNA Damage; Humans; Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Telomere - genetics

About 10% of all tumors, including most lower-grade astrocytoma, rely on the alternative lengthening of telomere (ALT) mechanism to resolve telomeric shortening and avoid limitations on their growth. Here, we found that dependence on the ALT mechanism made cells hypersensitive to a subset of poly(AD...