Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats

• Published in: Journal of complementary & integrative medicine Vol. 21; no. 2; pp. 175 - 183
• Main Authors: Minko Essono, Stéphane, Mvondo, Marie Alfrede, Wego, Marius Trésor Kamgaing, Kemka Nguimatio, François Xavier, Momo Tetsatsi, Aimé Césaire, Watcho, Pierre
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.06.2024
• Subjects: anti-estrogenic effects; estrogen-receptor antagonists; ovariectomized rat; anti-estrogenic effects; ovariectomized rat; Persea americana; estrogen-receptor antagonists

The ethanol extract of seeds was found to inhibit the development of estrogen-dependent conditions in female Wistar rats, suggesting the ability of its secondary metabolites to interact with estrogen receptors (ERs), either as partial agonists or as antagonists. To test this hypothesis, the abovemen...