WNT2b Activates Epithelial-mesenchymal Transition Through FZD4: Relevance in Penetrating Crohn´s Disease

• Published in: Journal of Crohn's and colitis Vol. 14; no. 2; pp. 230 - 239
• Main Authors: Ortiz-Masià, Dolores, Salvador, Pedro, Macias-Ceja, Dulce C, Gisbert-Ferrándiz, Laura, Esplugues, Juan V, Manyé, Josep, Alós, Rafael, Navarro-Vicente, Francisco, Mamie, Céline, Scharl, Michael, Cosin-Roger, Jesus, Calatayud, Sara, Barrachina, María D
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 10.02.2020
• Subjects: WNT pathway; Crohn´s disease; fibrosis

Abstract Background and Aims Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with Crohn´s disease [CD]. The WNT signalling pathway mediates EMT, and specific WNT/FZD interactions have been related to the activation of this p...