Effect of glycocalyx-targeted therapy on vascular function in older adults: a randomized controlled trial

• Published in: Journal of applied physiology (1985) Vol. 136; no. 6; p. 1488
• Main Authors: Gimblet, Colin J, Ernst, Jackson W, Bell, Blair, Bos, Kyle D, Stroud, Amy K, Wendt, Linder H, Donato, Anthony J, Jalal, Diana I, Pierce, Gary L
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2024
• Subjects: Adults; Aged; Antihypertensives; Brachial Artery - diagnostic imaging; Brachial Artery - drug effects; Brachial Artery - physiology; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - physiopathology; Disease control; Double-Blind Method; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Endothelium, Vascular - physiopathology; Female; Glycocalyx - drug effects; Glycocalyx - metabolism; Health risks; Humans; Male; Middle Aged; Older people; Placebos; Risk management; Shear rate; Supplements; Thickness measurement; Vasodilation - drug effects; Vasodilation - physiology; glycocalyx; endothelium; endocalyx

Advancing age increases cardiovascular disease risk, in part, because of impaired glycocalyx thickness and endothelial dysfunction. Glycocalyx-targeted therapies, such as Endocalyx Pro, could improve both glycocalyx thickness and endothelial function in older adults; however, this has yet to be test...