Identification of gene functional modules shared by cancers based on biclustering

• Published in: Yíchuán Vol. 35; no. 3; p. 333
• Main Authors: Zhang, Fan, Lin, Ai-Hua, Lin, Mei-Hua, Ding, Yuan-Lin, Rao, Shao-Qi
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2013
• Subjects: Computational Biology; Databases, Nucleic Acid; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Pleiotropy; Humans; Multigene Family; Neoplasms - genetics

Pleiotropy is a common phenomenon in the genetics of cancers, which is rarely systematically evaluated. A novel idea for identifying shared gene functional modules using biclustering was proposed in this paper to explore the common molecular mechanisms among cancers and the relationships between dif...